Description

3-Fluoropyridine-4-boronic acid (CAS No. 458532-97-3) is a high-purity boronic acid derivative with the molecular formula C₅H₅BFNO₂. This compound, also known by its IUPAC name (3-fluoropyridin-4-yl)boronic acid, is a versatile building block in organic synthesis and pharmaceutical research. Its unique structure, featuring a fluorine substituent on the pyridine ring, enhances its reactivity in Suzuki-Miyaura cross-coupling reactions, making it invaluable for constructing complex heterocyclic frameworks. Ideal for researchers and scientists, this product is rigorously tested for purity and stability, ensuring reliable performance in sensitive applications. Available in various quantities, it is supplied with comprehensive analytical data (including ¹H NMR, ¹³C NMR, and HPLC) to meet stringent research standards.

Properties

• CAS Number: 458532-97-3
• Complexity: 114
• IUPAC Name: (3-fluoro-4-pyridyl)boronic acid
• InChI: InChI=1S/C5H5BFNO2/c7-5-3-8-2-1-4(5)6(9)10/h1-3,9-10H
• InChI Key: QUHSESYLMZVXCN-UHFFFAOYSA-N
• Exact Mass: 141.0397367
• Molecular Formula: C5H5BFNO2
• Molecular Weight: 140.91
• SMILES: B(C1=C(C=NC=C1)F)(O)O
• Topological: 53.4
• Monoisotopic Mass: 141.0397367
• Synonyms: 3-Fluoropyridine-4-boronic acid, 458532-97-3, (3-fluoropyridin-4-yl)boronic Acid, DTXSID40381406, DTXCID20332431, 802-022-3, 3-Fluoropyridin-4-ylboronic acid, (3-FLUORO-4-PYRIDYL)BORONIC ACID, 3-fluoropyridin-4-yl-4-boronic acid, MFCD03788558, 3-fluoro-4-pyridylboronic acid, 3-Fluoropyridine-4-boronic Acid (contains varying amounts of Anhydride), BORONIC ACID, (3-FLUORO-4-PYRIDINYL)-, SCHEMBL667965, 3-fluoro-pyridine-4-boronic acid, QUHSESYLMZVXCN-UHFFFAOYSA-N, 3-fluoropyridin-4-yl-boronic acid, (3-fluoropyridin-4-yl)boronicAcid, BCP21918, SBB071139, (3-fluoropyridin-4-yl)-boronic acid, AKOS004119274, AB16034, CS-W007945, GS-6281, SY059498, DB-010594, 3-fluoropyridine-4-boronic acid, AldrichCPR, F1160, EN300-212517, I10120

Application

3-Fluoropyridine-4-boronic acid is widely used in pharmaceutical research as a key intermediate for synthesizing fluorinated pyridine derivatives, which are prevalent in drug discovery. Its boronic acid moiety facilitates Suzuki-Miyaura cross-coupling reactions, enabling the formation of biaryl structures common in bioactive molecules. Additionally, it serves as a precursor in materials science for developing fluorescent probes and ligands for catalysis. Researchers also utilize it to modify electronic properties of conjugated systems in organic electronics.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (75%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (75%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.