Description

2-Amino-6-chloropyridine (CAS No. 45644-21-1) is a high-purity heterocyclic organic compound with the molecular formula C₅H₅ClN₂. This fine chemical is widely utilized in pharmaceutical synthesis, agrochemical research, and as a versatile building block in organic chemistry. The compound features a pyridine ring substituted with an amino group at the 2-position and a chlorine atom at the 6-position, offering unique reactivity for nucleophilic substitution and cross-coupling reactions.

Our product is rigorously tested to ensure ≥98% purity (HPLC) and is supplied as a white to off-white crystalline powder. It is packaged under inert conditions to guarantee stability and longevity. Ideal for researchers in medicinal chemistry, this compound serves as a key intermediate in the development of active pharmaceutical ingredients (APIs) and specialty chemicals.

Storage recommendations: Keep container tightly sealed in a cool, dry, well-ventilated place at temperatures between 2-8°C. Handle with appropriate personal protective equipment (PPE) due to potential skin/eye irritation.

Properties

• CAS Number: 45644-21-1
• Complexity: 76.8
• IUPAC Name: 6-chloropyridin-2-amine
• InChI: InChI=1S/C5H5ClN2/c6-4-2-1-3-5(7)8-4/h1-3H,(H2,7,8)
• InChI Key: OBYJTLDIQBWBHM-UHFFFAOYSA-N
• Exact Mass: 128.0141259
• Molecular Formula: C5H5ClN2
• Molecular Weight: 128.56
• SMILES: C1=CC(=NC(=C1)Cl)N
• Topological: 38.9
• Monoisotopic Mass: 128.0141259
• Synonyms: 2-Amino-6-chloropyridine, 6-Chloro-2-pyridinamine, 629-259-3, 45644-21-1, 6-chloropyridin-2-amine, 2-Pyridinamine, 6-chloro-, 2-Chloro-6-aminopyridine, 6-chloropyridin-2-ylamine, MFCD00234068, Pyridine, 2-amino-6-chloro-, 6-chloro-pyridin-2-ylamine, BRN 0108669, 6-chloro-2-pyridylamine, 6-chloro-2-aminopyridine, 6-Amino-2-chloropyridine, 6-chloro-2-pyridinylamine, 2-chloro-6-amino-pyridine, 4-22-00-04028 (Beilstein Handbook Reference), SCHEMBL117748, 2-Amino-6-chloropyridine (6-Chloropyridin-2-ylamine), SCHEMBL2078173, SCHEMBL6304351, SCHEMBL10519825, SCHEMBL11547551, SCHEMBL16742864, DTXSID20196575, 2-Amino-6-chloropyridine, 97%, BCP22216, CL0045, SBB028231, AKOS000275942, AC-1411, CS-W002551, PB26011, PS-5492, SY003744, DB-010165, EN300-86280, AC-907/25004401, AJ-333/25006177

Application

2-Amino-6-chloropyridine is extensively used as a precursor in the synthesis of pharmaceutical compounds, particularly in the development of antiviral and antibacterial agents. The compound serves as a crucial intermediate for creating pyridine-based ligands in catalytic systems and metal-organic frameworks (MOFs). Researchers employ this chemical in palladium-catalyzed cross-coupling reactions (e.g., Suzuki-Miyaura) to construct complex heterocyclic architectures. Its reactive sites make it valuable for modifying nucleosides and creating novel agrochemicals.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (10.4%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (10.4%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (97.4%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Acute Tox. 4 (10.4%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (10.4%)
• STOT SE 3 (97.4%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.