Description

3-Fluorobenzaldehyde (CAS No. 456-48-4) is a high-purity aromatic aldehyde derivative widely utilized in pharmaceutical synthesis, agrochemical production, and advanced material research. This compound, with the molecular formula C₇H₅FO, features a fluorine substituent at the meta position of the benzaldehyde ring, enhancing its reactivity in nucleophilic addition and condensation reactions. Its excellent stability and compatibility with organic solvents make it a versatile intermediate for constructing fluorinated heterocycles, ligands, and fine chemicals. Available in >97% purity, our product undergoes rigorous QC testing (GC/HPLC, NMR) to ensure consistency for sensitive applications. Packed under inert gas in amber glass bottles to prevent degradation.

Properties

• CAS Number: 456-48-4
• Complexity: 103
• IUPAC Name: 3-fluorobenzaldehyde
• InChI: InChI=1S/C7H5FO/c8-7-3-1-2-6(4-7)5-9/h1-5H
• InChI Key: PIKNVEVCWAAOMJ-UHFFFAOYSA-N
• Exact Mass: 124.032442941
• Molecular Formula: C7H5FO
• Molecular Weight: 124.11
• SMILES: C1=CC(=CC(=C1)F)C=O
• Topological: 17.1
• Monoisotopic Mass: 124.032442941
• Synonyms: 3-Fluorobenzaldehyde, 456-48-4, Benzaldehyde, 3-fluoro-, meta-Fluorobenzaldehyde, 3-fluoro-benzaldehyde, 3-FC6H4CHO, EINECS 207-266-9, NSC 66830, DTXSID9060027, CHEBI:156102, DTXCID3040439, 207-266-9, inchi=1/c7h5fo/c8-7-3-1-2-6(4-7)5-9/h1-5, piknvevcwaaomj-uhfffaoysa-n, m-Fluorobenzaldehyde, Benzaldehyde, m-fluoro-, MFCD00003348, NSC-66830, 3′-fluoro-benzaldehyde, 3-Fluorobenzenecarboxaldehyde; 3-Fluorophenylcarboxaldehyde; NSC 66830; m-Fluorobenzaldehyde;, NSC66830, 3- Fluorobenzaldehyde, 3-fluoro benzaldehyde, 3-fluoranylbenzaldehyde, 3-Fluorobenzaldehyde, 97%, SCHEMBL24197, SCHEMBL98363, 3XU6KD28Y5, SCHEMBL1984415, SCHEMBL4044708, CHEMBL3884568, SCHEMBL15067042, SCHEMBL15068112, SBB040273, STK801410, AKOS000119734, CS-W013534, PS-9211, AC-10885, BP-20265, DB-003386, F0189, NS00044068, ST50213445, EN300-20045, A826866, Q18466560, F2190-0628, Z104476574

3-Fluorobenzaldehyde serves as a key precursor in Suzuki-Miyaura cross-coupling reactions for biaryl synthesis. Researchers employ it to develop fluorinated liquid crystals for display technologies due to its dipole-enhancing properties. The compound also acts as a building block for PET radiotracer development in neuroimaging studies. Its electron-withdrawing fluorine group facilitates regioselective electrophilic substitutions in medicinal chemistry workflows.

Safety and Hazards

GHS Hazard Statements

• H226 (98%): Flammable liquid and vapor [Warning Flammable liquids]
• H302 (17.6%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (98%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (96.1%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (98%)
• Acute Tox. 4 (17.6%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (98%)
• STOT SE 3 (96.1%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.