Description

4-(Trifluoromethyl)benzaldehyde (CAS No. 455-19-6) is a high-purity aromatic aldehyde featuring a trifluoromethyl group at the para position, making it a valuable intermediate in organic synthesis and pharmaceutical applications. With the molecular formula C₈H₅F₃O, this compound exhibits excellent reactivity due to its aldehyde functional group and electron-withdrawing trifluoromethyl moiety. It is widely utilized in the preparation of agrochemicals, pharmaceuticals, and specialty chemicals. Available in purities ≥97% (GC), our product is rigorously tested to ensure consistency, stability, and optimal performance in demanding synthetic processes. Packaged under inert conditions to prevent degradation, it is ideal for researchers and industrial chemists seeking reliable and high-quality reagents.

Properties

• CAS Number: 455-19-6
• Complexity: 156
• IUPAC Name: 4-(trifluoromethyl)benzaldehyde
• InChI: InChI=1S/C8H5F3O/c9-8(10,11)7-3-1-6(5-12)2-4-7/h1-5H
• InChI Key: BEOBZEOPTQQELP-UHFFFAOYSA-N
• Exact Mass: 174.02924926
• Molecular Formula: C8H5F3O
• Molecular Weight: 174.12
• SMILES: C1=CC(=CC=C1C=O)C(F)(F)F
• Topological: 17.1
• Monoisotopic Mass: 174.02924926
• Synonyms: 4-(Trifluoromethyl)benzaldehyde, 455-19-6, Benzaldehyde, 4-(trifluoromethyl)-, p-(Trifluoromethyl)benzaldehyde, EINECS 207-240-7, DTXSID0060016, 4-(trifluoromethyl)-benzaldehyde, Para-(trifluoromethyl)benzaldehyde, DTXCID4040424, 207-240-7, 4-Trifluoromethylbenzaldehyde, 1-Formyl-4-trifluoromethylbenzene, p-Trifluoromethylbenzaldehyde, MFCD00006952, alpha,alpha,alpha-Trifluoro-p-tolualdehyde, 4-trifluoromethyl benzaldehyde, .alpha.,.alpha.,.alpha.-Trifluoro-p-tolualdehyde, 4′-trifluoromethyl benzaldehyde, 4-trifluoromethyl-benzaldehyde, A,A,A-TRIFLUORO-P-TOLUALDEHYDE, trifluoro-p-tolualdehyde, p-CF3C6H4CHO, 4-trifluormethylbenzaldehyde, 4-trifluromethylbenzaldehyde, SCHEMBL61631, SCHEMBL99050, 4-(trifluormethyl)-benzaldehyde, a,a,a-tri-fluoro-p-tolualdehyde, CHEMBL4473405, SCHEMBL27999391, SCHEMBL28056597, 4-(trifluoromethyl) benzaldehyde, (4-trifluoromethylphenyl)methanone, CHEBI:156309, SBB040270, 4-(Trifluoromethyl)benzaldehyde, 98%, 4-Trifluoromethylbenzaldehyde (alpha,alpha,alpha-Trifluoro-p-tolualdehyde), AKOS000118848, AC-3867, CS-W008968, PS-8631, alpha,alpha,alpha-trifluro-p-tolualdehyde, SY003301, DB-014388, NS00043594, ST50213440, T1091, EN300-19394, P17751, 4-(Trifluoromethyl)benzaldehyde, purum, >=97.0% (GC), F2190-0584, Z104473706, InChI=1/C8H5F3O/c9-8(10,11)7-3-1-6(5-12)2-4-7/h1-5, p-(Trifluoromethyl)benzaldehyde; alpha,alpha,alpha-Trifluoro-p-tolualdehyde

4-(Trifluoromethyl)benzaldehyde is extensively used as a key building block in the synthesis of trifluoromethyl-substituted pharmaceuticals, including antiviral and anticancer agents. Its electron-deficient aromatic ring enhances reactivity in nucleophilic addition and condensation reactions, making it valuable for constructing complex heterocycles. Additionally, it serves as a precursor for liquid crystal materials and agrochemical intermediates. The trifluoromethyl group imparts metabolic stability and lipophilicity, enhancing the bioavailability of derived compounds.

Safety and Hazards

GHS Hazard Statements

• H302 (16.4%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (94.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (16.4%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (94.5%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.