Description

4-Trifluoromethylaniline (CAS No. 455-14-1) is a high-purity aromatic amine compound with the molecular formula C₇H₆F₃N, widely utilized in pharmaceutical synthesis, agrochemical production, and advanced material research. This organic intermediate features a trifluoromethyl group (–CF₃) at the para position of an aniline ring, enhancing its electron-withdrawing properties and making it invaluable for nucleophilic substitution reactions, cross-coupling, and as a precursor for fluorinated heterocycles. Available in >99% purity (GC), it is supplied as a clear to pale-yellow liquid with a characteristic amine odor, packaged under inert gas to ensure stability. Ideal for laboratories and industrial-scale applications requiring rigorous quality control (QC) via HPLC, NMR, and MS analysis. Store at 2–8°C in a tightly sealed container to prevent oxidation.

Properties

• CAS Number: 455-14-1
• Complexity: 124
• IUPAC Name: 4-(trifluoromethyl)aniline
• InChI: InChI=1S/C7H6F3N/c8-7(9,10)5-1-3-6(11)4-2-5/h1-4H,11H2
• InChI Key: ODGIMMLDVSWADK-UHFFFAOYSA-N
• Exact Mass: 161.04523368
• Molecular Formula: C7H6F3N
• Molecular Weight: 161.12
• SMILES: C1=CC(=CC=C1C(F)(F)F)N
• Topological: 26
• Monoisotopic Mass: 161.04523368
• Synonyms: 4-(Trifluoromethyl)aniline, 455-14-1, 4-Aminobenzotrifluoride, 4-Trifluoromethylaniline, p-Aminobenzotrifluoride, p-Trifluoromethylaniline, Benzenamine, 4-(trifluoromethyl)-, p-(Trifluoromethyl)aniline, 4-(Trifluoromethyl)benzenamine, Aniline, p-(trifluoromethyl)-, NSC 10337, p-Amino-alpha,alpha,alpha-trifluorotoluene, EINECS 207-236-5, RQJ623MB8G, BRN 1564853, CHEBI:40750, para-trifluoromethylaniline, NSC-10337, 4-TFMA, DTXSID5060013, p-TOLUIDINE, alpha,alpha,alpha-TRIFLUORO-, EC 207-236-5, 4-12-00-01982 (Beilstein Handbook Reference), (4-(TRIFLUOROMETHYL)PHENYL)AMINE, TERIFLUNOMIDE METABOLITE (4-TFMA), LEFLUNOMIDE IMPURITY A [EP IMPURITY], [4-(trifluoromethyl)phenyl]amine, LEFLUNOMIDE IMPURITY A (EP IMPURITY), DTXCID9040421, inchi=1/c7h6f3n/c8-7(9,10)5-1-3-6(11)4-2-5/h1-4h,11h, MFCD00064396, alpha,alpha,alpha-Trifluoro-p-toluidine, 4-Trifluoromethyl-phenylamine, 1-amino-4-(trifluoromethyl)benzene, 4-(trifluoromethyl)phenylamine, EN300-20241, .alpha.,.alpha.,.alpha.-Trifluoro-p-toluidine, aniline, 4-trifluoromethyl-, a,a,a-trifluoro-p-toluidine, 4-(trifluoromethyl) aniline, UNII-RQJ623MB8G, LEFLUNOMIDE IMPURITY A, 4-trifluormethylaniline, 4-amino benzotrifluoride, 4-amino-benzotrifluoride, 4-Aminobenzotrifluororide, para-aminobenzotrifluoride, 4-trifluoromethyl aniline, 4-trifluoromethyl-aniline, 4-trifluoro methyl aniline, 4-trifluoromethylphenylamine, 4-(trifluoromethyl)-aniline, 4-trifluoromethyl phenylamine, SCHEMBL10302, SCHEMBL67917, 4-(trifluoro methyl) aniline, SCHEMBL272417, 4-trifluoromethyl phenyl amine, SCHEMBL6223209, 4-(trifluoromethyl)benzenaminium, CHEMBL1162294, GCGAKNYKKHXOJP-UHFFFAOYSA-N, XSALEIBQORDDCL-UHFFFAOYSA-N, 4-(Trifluoromethyl)aniline, 99%, BDBM626085, NSC10337, [4- (trifluoromethyl)phenyl] amine, [4-(trifluoromethyl)-phenyl]-amine, AC-028, SBB003956, STL164343, AKOS000119383, .alpha.,.alpha.-Trifluoro-p-anisidine, .alpha.,.alpha.-Trifluoro-p-toluidine, CS-W019629, FA00019, PS-8765, p-Toluidine,.alpha.,.alpha.-trifluoro-, p-Amino-.alpha.,.alpha.-trifluorotoluene, A0662, NS00007445, ST50406472, D77859, 4-Aminobenzotrifluoride hydrochloride (Salt/Mix), 4-Amino-.alpha.,.alpha.,.alpha.-benzotrifluoride, p-Amino-.alpha.,.alpha.,.alpha.-trifluorotoluene, p-Toluidine, .alpha.,.alpha.,.alpha.-trifluoro-, Q27120406, F2190-0436, Z104477456, Leflunomide impurity A, European Pharmacopoeia (EP) Reference Standard

4-Trifluoromethylaniline is a key building block in the synthesis of active pharmaceutical ingredients (APIs), including leflunomide metabolites and fluorinated analogs. It serves as a versatile intermediate in Suzuki-Miyaura couplings for agrochemicals and OLED materials. Researchers also employ it to develop corrosion inhibitors and specialty polymers. Handle with appropriate PPE due to moderate toxicity.

Safety and Hazards

GHS Hazard Statements

• H301 (66.1%): Toxic if swallowed [Danger Acute toxicity, oral]
• H318 (18.3%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (47.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H331 (17.4%): Toxic if inhaled [Danger Acute toxicity, inhalation]
• H372 (17.4%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]
• H400 (63.3%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
• H410 (64.2%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P260, P261, P264, P264+P265, P270, P271, P273, P280, P301+P316, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P330, P337+P317, P391, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (66.1%)
• Eye Dam. 1 (18.3%)
• Eye Irrit. 2 (47.7%)
• Acute Tox. 3 (17.4%)
• STOT RE 1 (17.4%)
• Aquatic Acute 1 (63.3%)
• Aquatic Chronic 1 (64.2%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.