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Atomfair 2-Chloro-5-nitropyridine C5H3ClN2O2 CAS 4548-45-2

2-Chloro-5-nitropyridine (CAS No. 4548-45-2) is a high-purity heterocyclic organic compound with the molecular formula C5H3ClN2O2. This pale yellow to off-white crystalline solid is a versatile intermediate in pharmaceutical, agrochemical, and specialty chemical synthesis. With a molecular weight of 158.54 g/mol, it features a reactive chloro group at the 2-position and an electron-withdrawing nitro group at the 5-position, making it ideal for nucleophilic substitution and cross-coupling reactions. Our product is rigorously tested to ensure ≥98% purity (HPLC) and is supplied in sealed containers under inert atmosphere to prevent degradation. Suitable for use in Suzuki, Stille, and Buchwald-Hartwig reactions.

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Description

2-Chloro-5-nitropyridine (CAS No. 4548-45-2) is a high-purity heterocyclic organic compound with the molecular formula C5H3ClN2O2. This pale yellow to off-white crystalline solid is a versatile intermediate in pharmaceutical, agrochemical, and specialty chemical synthesis. With a molecular weight of 158.54 g/mol, it features a reactive chloro group at the 2-position and an electron-withdrawing nitro group at the 5-position, making it ideal for nucleophilic substitution and cross-coupling reactions. Our product is rigorously tested to ensure ≥98% purity (HPLC) and is supplied in sealed containers under inert atmosphere to prevent degradation. Suitable for use in Suzuki, Stille, and Buchwald-Hartwig reactions.

Properties

  • CAS Number: 4548-45-2
  • Complexity: 136
  • IUPAC Name: 2-chloro-5-nitro-pyridine
  • InChI: InChI=1S/C5H3ClN2O2/c6-5-2-1-4(3-7-5)8(9)10/h1-3H
  • InChI Key: BAZVFQBTJPBRTJ-UHFFFAOYSA-N
  • Exact Mass: 157.9883050
  • Molecular Formula: C5H3ClN2O2
  • Molecular Weight: 158.54
  • SMILES: C1=CC(=NC=C1[N+](=O)[O-])Cl
  • Topological: 58.7
  • Monoisotopic Mass: 157.9883050
  • Synonyms: 2-Chloro-5-nitropyridine, 4548-45-2, Pyridine, 2-chloro-5-nitro-, EINECS 224-908-3, NSC 4468, BRN 0120453, AI3-19230, DTXSID70196525, 5-20-05-00452 (Beilstein Handbook Reference), DTXCID10119016, 224-908-3, 4585-45-2, bazvfqbtjpbrtj-uhfffaoysa-n, inchi=1/c5h3cln2o2/c6-5-2-1-4(3-7-5)8(9)10/h1-3, 2-chloro-5-nitro-pyridine, 3-Nitro-6-chloropyridine, 2-chloro-5-nitro pyridine, MFCD00006240, 34515-81-6, NSC-4468, 5-nitro-2-chloropyridine, NSC4468, chloro-5-nitropyridine, 2chloro-5-nitropyridine, 2-chloro-5-nitropyridin, 2-cloro-5-nitropyridine, 6-chloro-3-nitropyridine, 2-chloro-5-riitropyridine, 2-chloro -5-nitropyridine, 2-chloro–5-nitropyridine, 5-nitro-2-chloro pyridine, 5-nitro-2-chloro-pyridine, WLN: T6NJ BG ENW, SCHEMBL5473, 2-chloro-5-(nitro)pyridine, SCHEMBL1531229, SCHEMBL14145676, SCHEMBL28717323, 2-Chloro-5-nitropyridine, 99%, 6L92DZ2L45, BCP26970, STR00179, BBL009800, RB1109, SBB054353, STK801263, AKOS000120380, AB00655, AC-2462, CS-W013280, FC00121, FG-0498, HY-W012564, NCGC00334089-01, BP-11373, DB-005226, A7161, NS00031538, ST50208947, EN300-18310, AB00443457-03, AC-907/30002041, 2-Chloro-5-nitropyridine, purum, >=97.0% (AT), Q63391986, Z57834470, F3284-7504

Application

2-Chloro-5-nitropyridine serves as a key building block in the synthesis of pharmaceutical compounds, particularly for antiviral and antibacterial agents. It is widely employed in agrochemical production for creating novel pesticides and herbicides. Researchers utilize this compound as a precursor in the development of liquid crystals and other advanced materials.

Safety and Hazards

GHS Hazard Statements

  • H302 (14%): Harmful if swallowed [Warning Acute toxicity, oral]
  • H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H335 (98%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Acute Tox. 4 (14%)
  • Skin Irrit. 2 (100%)
  • Eye Irrit. 2 (100%)
  • STOT SE 3 (98%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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