Description

2-Fluoro-5-methylaniline (CAS No. 452-84-6) is a high-purity aromatic amine derivative with the molecular formula C₇H₈FN. This specialized organic compound is widely utilized in pharmaceutical research, agrochemical synthesis, and advanced material science due to its unique fluoro- and methyl-substituted aniline structure. Our product is rigorously tested to ensure ≥99% purity (GC) and optimal stability, making it ideal for sensitive applications. Supplied in amber glass vials under inert atmosphere to prevent degradation, it features low moisture content (<0.5% water) and meets stringent analytical standards (HPLC, NMR verified). Key identifiers include MFCD00007654 and InChIKey QZUXMXZNVAJNSE-UHFFFAOYSA-N. Suitable for use as a versatile building block in Suzuki couplings, palladium-catalyzed aminations, and heterocycle formation.

Properties

• CAS Number: 452-84-6
• Complexity: 94.9
• IUPAC Name: 2-fluoro-5-methyl-aniline
• InChI: InChI=1S/C7H8FN/c1-5-2-3-6(8)7(9)4-5/h2-4H,9H2,1H3
• InChI Key: QZUXMXZNVAJNSE-UHFFFAOYSA-N
• Exact Mass: 125.064077422
• Molecular Formula: C7H8FN
• Molecular Weight: 125.14
• SMILES: CC1=CC(=C(C=C1)F)N
• Topological: 26
• Monoisotopic Mass: 125.064077422
• Synonyms: 2-Fluoro-5-methylaniline, 452-84-6, 6-Fluoro-m-toluidine, Benzenamine, 2-fluoro-5-methyl-, QZUXMXZNVAJNSE-UHFFFAOYSA-, DTXSID90294557, DTXCID00245696, 610-239-8, inchi=1/c7h8fn/c1-5-2-3-6(8)7(9)4-5/h2-4h,9h2,1h3, qzuxmxznvajnse-uhfffaoysa-n, 3-Amino-4-fluorotoluene, 2-fluoro-5-methylbenzenamine, 2-Fluoro-5-methylphenylamine, MFCD00007654, 2-fluoro-5-methyl-aniline, NSC97095, 2-fluoro-5-metylaniline, 2-fluoro-5-methyl aniline, SCHEMBL59217, SCHEMBL652313, SCHEMBL7362828, 2-Fluoro-5-methylaniline, 99%, CS-D0820, NSC-97095, SBB028213, STL169016, AKOS000120076, AC-3687, CCG-302498, DS-0875, PS-9196, SB10519, DB-024067, F0528, NS00124880, ST45028479, EN300-20587, 2-Fluoro-5-methylbenzeneamine; 6-Fluoro-m-toluidine, Z104479030

2-Fluoro-5-methylaniline serves as a critical intermediate in the synthesis of bioactive molecules, particularly in developing kinase inhibitors and antimicrobial agents. Its electron-withdrawing fluorine and electron-donating methyl group enable precise modulation of electronic properties in drug candidates. The compound is frequently employed in the preparation of liquid crystal materials and organic semiconductors due to its stable aromatic system. Researchers also utilize it as a directing group in transition metal-catalyzed C-H functionalization reactions.

Safety and Hazards

GHS Hazard Statements

• H302 (14.3%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (14.3%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (87.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H373 (10.2%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

Precautionary Statements

• P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (14.3%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (14.3%)
• STOT SE 3 (87.8%)
• STOT RE 2 (10.2%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.