Description

3-Fluoro-4-methylaniline (CAS No. 452-77-7) is a high-purity fluorinated aromatic amine with the molecular formula C₇H₈FN. This compound is a valuable intermediate in organic synthesis, particularly in the pharmaceutical and agrochemical industries. Its unique structure, featuring both a fluorine substituent and a methyl group on the aniline ring, makes it a versatile building block for the development of novel active ingredients.

Our product is rigorously tested to ensure exceptional quality, with purity levels meeting the stringent requirements of research and industrial applications. It is supplied in a stable, well-packaged form to maintain integrity during storage and transport. Ideal for researchers and scientists working on advanced chemical synthesis, 3-Fluoro-4-methylaniline offers reliable performance in coupling reactions, heterocycle formation, and other specialized transformations.

Properties

• CAS Number: 452-77-7
• Complexity: 94.9
• IUPAC Name: 3-fluoro-4-methyl-aniline
• InChI: InChI=1S/C7H8FN/c1-5-2-3-6(9)4-7(5)8/h2-4H,9H2,1H3
• InChI Key: MGRHBBRSAFPBIN-UHFFFAOYSA-N
• Exact Mass: 125.064077422
• Molecular Formula: C7H8FN
• Molecular Weight: 125.14
• SMILES: CC1=C(C=C(C=C1)N)F
• Topological: 26
• Monoisotopic Mass: 125.064077422
• Synonyms: 3-Fluoro-4-methylaniline, 452-77-7, Benzenamine, 3-fluoro-4-methyl-, EINECS 207-212-4, NSC 57470, BRN 2715987, DTXSID80196430, DTXCID90118921, Benzenamine, 3-fluoro-4-methyl-(9CI), 4-12-00-01981 (beilstein handbook reference), inchi=1/c7h8fn/c1-5-2-3-6(9)4-7(5)8/h2-4h,9h2,1h, mgrhbbrsafpbin-uhfffaoysa-n, 4-Amino-2-fluorotoluene, 3-Fluoro-p-toluidine, 2-Fluoro-4-aminotoluene, p-TOLUIDINE, 3-FLUORO-, MFCD00007762, 3-fluoro-4-methylphenylamine, 3-fluoro-4-methylbenzenamine, NSC-57470, 3-fluoro-4-methyl-aniline, NSC57470, 3-Fluor-p-toluidin, Benzenamine, 3-fluoro-4-methyl- (9CI), PCG9PMZ9Y7, 3-fluoro-4-methyl aniline, WLN: ZR CF D1, SCHEMBL347254, SCHEMBL654123, 3-fluoro-4-methyl-phenylamine, SCHEMBL28872401, 3-Fluoro-4-methylaniline, 99%, BBL100253, SBB028219, STL195539, AKOS000113236, AC-3689, CS-W013514, PS-9194, FF104392, SY013813, DB-024065, A7141, F0440, NS00043997, ST51038066, EN300-20223, 3-Fluoro-4-methylbenzeneamine; 3-Fluoro-p-toluidine, F2190-0475, Z104477330

Application

3-Fluoro-4-methylaniline is widely used as a key intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. Its fluorinated aromatic structure is particularly valuable in the development of active pharmaceutical ingredients (APIs) and crop protection agents. Researchers also utilize this compound in material science for the creation of advanced polymers and dyes.

Safety and Hazards

GHS Hazard Statements

• H300 (83.7%): Fatal if swallowed [Danger Acute toxicity, oral]
• H302 (10.2%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (93.9%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (91.8%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (91.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (93.9%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (87.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H373 (10.2%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

Precautionary Statements

• P260, P261, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 1 (83.7%)
• Acute Tox. 4 (10.2%)
• Acute Tox. 4 (93.9%)
• Skin Irrit. 2 (91.8%)
• Eye Irrit. 2 (91.8%)
• Acute Tox. 4 (93.9%)
• STOT SE 3 (87.8%)
• STOT RE 2 (10.2%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.