Description

4-Fluoro-3-methylphenol (CAS: 452-70-0) is a high-purity fluorinated phenolic compound with the molecular formula C₇H₇FO. This specialty chemical is widely utilized in pharmaceutical synthesis, agrochemical development, and advanced material research due to its unique structural properties. With a purity of ≥98%, our product is rigorously tested via GC/MS, HPLC, and NMR to ensure compliance with industry standards. Ideal for researchers and scientists, this compound serves as a versatile building block for heterocyclic chemistry, cross-coupling reactions, and fluorinated intermediates. Packaged under inert gas to prevent degradation, it is supplied in amber glass vials with secure closures for optimal stability.

Properties

• CAS Number: 452-70-0
• Complexity: 94.9
• IUPAC Name: 4-fluoro-3-methyl-phenol
• InChI: InChI=1S/C7H7FO/c1-5-4-6(9)2-3-7(5)8/h2-4,9H,1H3
• InChI Key: RVYGYYVGWSCWGY-UHFFFAOYSA-N
• Exact Mass: 126.048093005
• Molecular Formula: C7H7FO
• Molecular Weight: 126.13
• SMILES: CC1=C(C=CC(=C1)O)F
• Topological: 20.2
• Monoisotopic Mass: 126.048093005
• Synonyms: 4-Fluoro-3-methylphenol, 452-70-0, DTXSID40372036, DTXCID00323069, 610-234-0, 4-Fluoro-m-cresol, 3-METHYL-4-FLUOROPHENOL, MFCD00042296, Phenol, 4-fluoro-3-methyl-, 4-fluoro-3-methyl-phenol, 4-fluoro-3-methyl phenol, SCHEMBL230046, SCHEMBL1607610, SCHEMBL5661333, SCHEMBL27600030, 4-Fluoro-3-methylphenol, 98%, RVYGYYVGWSCWGY-UHFFFAOYSA-N, SBB085652, AKOS005255595, CS-W002208, FF69981, PS-9178, SY019177, DB-024059, F0429, NS00125160, EN300-68180, Z1021305330

4-Fluoro-3-methylphenol is primarily used as a key intermediate in the synthesis of fluorinated pharmaceuticals and agrochemicals. Its reactive phenolic hydroxyl group and fluorine substitution make it valuable for designing bioactive molecules with enhanced metabolic stability. Researchers also employ it in material science to modify polymer properties or as a precursor for advanced coatings. The compound’s compatibility with palladium-catalyzed reactions further expands its utility in medicinal chemistry.

Safety and Hazards

GHS Hazard Statements

• H302 (17.6%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (17.6%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H314 (15.7%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H315 (82.4%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (82.4%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (80.4%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P363, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (17.6%)
• Acute Tox. 4 (17.6%)
• Skin Corr. 1B (15.7%)
• Skin Irrit. 2 (82.4%)
• Eye Irrit. 2 (82.4%)
• STOT SE 3 (80.4%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.