Description

5-Fluoro-2-nitroanisole (CAS No. 448-19-1) is a high-purity fluorinated nitroaromatic compound with the molecular formula C₇H₆FNO₃ and IUPAC name 4-fluoro-2-methoxy-1-nitrobenzene. This yellow crystalline solid is a valuable intermediate in organic synthesis, particularly in pharmaceutical and agrochemical research. With a molecular weight of 171.13 g/mol, it exhibits excellent stability under standard laboratory conditions. Our product is rigorously tested to ensure ≥98% purity (HPLC) and is supplied in sealed amber vials to prevent degradation. Ideal for nucleophilic substitution reactions, cross-coupling protocols, and as a precursor for fluorinated heterocycles. Available in gram to kilogram quantities with optional COA and NMR analysis reports.

Properties

• CAS Number: 448-19-1
• Complexity: 171
• IUPAC Name: 4-fluoro-2-methoxy-1-nitro-benzene
• InChI: InChI=1S/C7H6FNO3/c1-12-7-4-5(8)2-3-6(7)9(10)11/h2-4H,1H3
• InChI Key: WLKUSVNHZXUEFO-UHFFFAOYSA-N
• Exact Mass: 171.03317122
• Molecular Formula: C7H6FNO3
• Molecular Weight: 171.13
• SMILES: COC1=C(C=CC(=C1)F)[N+](=O)[O-]
• Topological: 55.1
• Monoisotopic Mass: 171.03317122
• Synonyms: 5-Fluoro-2-nitroanisole, 448-19-1, DTXSID90381350, DTXCID20332375, 675-631-3, 4-Fluoro-2-methoxy-1-nitrobenzene, 3-fluoro-6-nitroanisole, 2-Nitro-5-fluoroanisole, MFCD00077541, BENZENE, 4-FLUORO-2-METHOXY-1-NITRO-, 1-fluoro-3-methoxy-4-nitrobenzene, 4-fluoro-2-(methyloxy)-1-nitrobenzene, 4-fluoro-2-methoxy-1-nitro-benzene, 4-FLUORO-2-METHOXYNITROBENZENE, 5-FLUORO-2-NITROPHENYL METHYL ETHER, 2-nitro-5-fluoro-anisole, SCHEMBL221284, 2-methoxy-4-fluoronitrobenzene, 3-methoxy-4-nitrofluorobenzene, 5T25M39NND, 2-methoxy-4-fluoronitro-benzene, 4-fluoro-2-methoxy-nitrobenzene, SCHEMBL27335613, 2-Methoxy-4-fluoro-1-nitrobenzene, BCP18514, CS-B0932, 4-Fluoro-2-methoxy-1 -nitrobenzene, SBB064432, AKOS005073340, AB02974, FF34208, LB-0734, SY004832, DB-024049, F0703, EN300-72156, F0001-2669

Application

5-Fluoro-2-nitroanisole serves as a key building block in medicinal chemistry for developing fluorinated drug candidates, particularly kinase inhibitors and antimicrobial agents. Researchers utilize its nitro group for reduction to amines or conversion to other functional groups in multi-step syntheses. The compound’s fluorine atom enhances metabolic stability in bioactive molecules, making it valuable for structure-activity relationship (SAR) studies. It’s also employed in material science for creating fluorinated liquid crystals and electronic materials.

Safety and Hazards

GHS Hazard Statements

• H302 (85.1%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (14.9%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (14.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (12.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (85.1%)
• Skin Irrit. 2 (14.9%)
• Eye Irrit. 2A (14.9%)
• STOT SE 3 (12.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.