Description

4-Chloro-2-(trifluoromethyl)aniline (CAS No. 445-03-4) is a high-purity aromatic amine derivative with the molecular formula C₇H₅ClF₃N. This compound features a chloro-substituted benzene ring and a trifluoromethyl group at the ortho position relative to the amino group, making it a versatile intermediate in organic synthesis. Its unique structure imparts both electron-withdrawing and steric effects, which are valuable in the development of pharmaceuticals, agrochemicals, and specialty materials. Available in >98% purity (GC), this product is rigorously tested for consistency and suitability in sensitive applications. Packaged under inert gas to ensure stability, it is ideal for researchers requiring precise functionalization in heterocyclic and fluorinated compound synthesis.

Properties

• CAS Number: 445-03-4
• Complexity: 159
• IUPAC Name: 4-chloro-2-(trifluoromethyl)aniline
• InChI: InChI=1S/C7H5ClF3N/c8-4-1-2-6(12)5(3-4)7(9,10)11/h1-3H,12H2
• InChI Key: CVINWVPRKDIGLL-UHFFFAOYSA-N
• Exact Mass: 195.0062613
• Molecular Formula: C7H5ClF3N
• Molecular Weight: 195.57
• SMILES: C1=CC(=C(C=C1Cl)C(F)(F)F)N
• Topological: 26
• Monoisotopic Mass: 195.0062613
• Synonyms: Benzenamine, 4-chloro-2-(trifluoromethyl)-, 2-Trifluoromethyl-4-chloroaniline, EINECS 207-151-3, EC 207-151-3, 2-Amino-5-chlorobenzotrifluoride, 445-03-4, 4-Chloro-2-(trifluoromethyl)aniline, 4-Chloro-2-trifluoromethylaniline, 5-Chloro-2-aminobenzotrifluoride, MFCD00007841, 4-Chloro-alpha,alpha,alpha-trifluoro-o-toluidine, o-Toluidine, 4-chloro-.alpha.,.alpha.,.alpha.-trifluoro-, 2-amino-5-chloro-trifluorotoluene, 4-chloro-2-(trifluoromethyl)phenylamine, Fast Scarlet VD Salt, Scarlet Salt NVD, 4-Chloro-2-trifluoromethyl-phenylamine, Fast Scarlet Salt VD, Diazo Fast Scarlet VD, SCHEMBL184916, DTXSID6060000, SCHEMBL27389128, SCHEMBL27913900, 5-Chloro-2-aminotrifluorotoluene, C.I. Azoic Diazo Component 17, FA1-1, 4-chloro-2-trifluoromethyl aniline, 4-chloro-2-trifluoromethyl-aniline, SBB000345, STL169031, 4-Chloro-a,a,a-trifluoro-o-toluidine, AKOS000119431, Aniline, 4-chloro-2-trifluoromethyl-, CS-W010616, FC64327, PS-8283, AC-10155, AC-13853, BP-20463, 4-Chloro-2-(trifluoromethyl)aniline, 97%, A1058, C.I. 37055, NS00001746, ST50213781, EN300-20221, 4-Chloro-.alpha.,.alpha.,.alpha.-trifluoro-o-toluidine, F0001-1211

Application

4-Chloro-2-(trifluoromethyl)aniline serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for antimalarial and antiviral agents. Its trifluoromethyl group enhances metabolic stability in agrochemicals, such as herbicides and fungicides. The compound is also employed in materials science for creating fluorinated polymers with improved thermal and chemical resistance.

Safety and Hazards

GHS Hazard Statements

• H302 (96%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (90%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (98%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (90%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (86%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H373 (80%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

Precautionary Statements

• P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (96%)
• Acute Tox. 4 (90%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (98%)
• Acute Tox. 4 (90%)
• STOT SE 3 (86%)
• STOT RE 2 (80%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.