Description

1,3-Difluoro-2-methylbenzene (CAS No. 443-84-5) is a high-purity aromatic compound with the molecular formula C₇H₆F₂. This fluorinated toluene derivative is widely used in organic synthesis, pharmaceutical intermediates, and agrochemical research due to its versatile reactivity and stability. It is available in various purity grades (98%, 99%) to meet rigorous laboratory and industrial standards. The compound is characterized by its clear liquid form, low volatility, and compatibility with a range of solvents. Suitable for use in cross-coupling reactions, fluorination studies, and as a building block for advanced materials. Packaged in amber glass bottles under inert gas to ensure long-term stability and prevent degradation.

Properties

• CAS Number: 443-84-5
• Complexity: 82.9
• IUPAC Name: 1,3-difluoro-2-methyl-benzene
• InChI: InChI=1S/C7H6F2/c1-5-6(8)3-2-4-7(5)9/h2-4H,1H3
• InChI Key: MZLSNIREOQCDED-UHFFFAOYSA-N
• Exact Mass: 128.04375652
• Molecular Formula: C7H6F2
• Molecular Weight: 128.12
• SMILES: CC1=C(C=CC=C1F)F
• Monoisotopic Mass: 128.04375652
• Synonyms: 2,6-Difluorotoluene, 443-84-5, 1,3-Difluoro-2-methylbenzene, MZLSNIREOQCDED-UHFFFAOYSA-, DTXSID00963202, DTXCID701019582, 623-587-0, inchi=1/c7h6f2/c1-5-6(8)3-2-4-7(5)9/h2-4h,1h3, BENZENE, 1,3-DIFLUORO-2-METHYL-, 2,6-difluoro-toluene, 1,3-DIFLUORO-2-METHYL-BENZENE, QJL3T73K6Q, 2,6-Difluoro(methyl)benzene, 2,6-Difluorotoluene, 98%, 2,6-Difluorotoluene, 99%, SCHEMBL131867, SCHEMBL254224, SCHEMBL456064, SCHEMBL584226, SCHEMBL2094249, SCHEMBL9545081, 1,3-Difluoro-2-methylbenzene #, MFCD00043898, SBB085711, AKOS006222504, AC-9824, FD58286, DB-024024, D2338, EN300-366965

1,3-Difluoro-2-methylbenzene serves as a key intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. It is commonly employed in Suzuki-Miyaura coupling reactions to introduce fluorinated aromatic groups. Researchers also utilize it in the development of liquid crystals and polymers due to its electron-withdrawing properties. Its stability under acidic conditions makes it ideal for multi-step synthetic routes.

Safety and Hazards

GHS Hazard Statements

• H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]
• H315 (10.6%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (10.6%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (10.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 2 (100%)
• Skin Irrit. 2 (10.6%)
• Eye Irrit. 2 (10.6%)
• STOT SE 3 (10.6%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.