Description

2,2-Difluoropropane-1,3-diol (CAS No. 428-63-7) is a high-purity fluorinated diol with the molecular formula C₃H₆F₂O₂, widely utilized in advanced organic synthesis and material science applications. This compound features two hydroxyl groups and two fluorine atoms on a propane backbone, offering unique reactivity for crosslinking, polymerization, and derivatization. Available in >98% purity (GC), it is supplied as a clear, colorless liquid with strict quality control to ensure consistency for research and industrial use. Ideal for developing fluorinated polymers, pharmaceutical intermediates, and specialty coatings. Store under inert atmosphere at 2-8°C to maintain stability.

Properties

• CAS Number: 428-63-7
• Complexity: 48.9
• IUPAC Name: 2,2-difluoropropane-1,3-diol
• InChI: InChI=1S/C3H6F2O2/c4-3(5,1-6)2-7/h6-7H,1-2H2
• InChI Key: AMCKYDINHDOOCB-UHFFFAOYSA-N
• Exact Mass: 112.03358575
• Molecular Formula: C3H6F2O2
• Molecular Weight: 112.08
• SMILES: C(C(CO)(F)F)O
• Topological: 40.5
• Monoisotopic Mass: 112.03358575
• Synonyms: 2,2-difluoropropane-1,3-diol, 807-402-2, 428-63-7, 2,2-DIFLUORO-1,3-PROPANEDIOL, 1,3-Propanediol, 2,2-difluoro-, MFCD16619633, C3H6F2O2, NSC32744, NSC 32744, SCHEMBL711852, SCHEMBL1461572, DTXSID20195487, BBL101726, NSC-32744, STL555523, AKOS007930412, PB42807, AS-48669, SY026989, DB-181538, CS-0094694, EN300-153017, F52367, F8887-5540

Application

2,2-Difluoropropane-1,3-diol serves as a key building block for synthesizing fluorinated polyesters and polyurethanes with enhanced chemical resistance. Its dual hydroxyl functionality enables use in crosslinking agents for high-performance coatings and adhesives. Researchers also employ it as a precursor for bioactive molecules in medicinal chemistry due to the fluorine moiety’s metabolic stability.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (100%)

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