Description

1-Bromo-4-(trifluoromethoxy)benzene (CAS: 407-14-7) is a high-purity aromatic compound with the molecular formula C₇H₄BrF₃O. This organobromine derivative features a trifluoromethoxy group at the para position of the benzene ring, making it a valuable intermediate in organic synthesis, pharmaceuticals, and agrochemical research. Its unique electronic and steric properties enhance reactivity in cross-coupling reactions, nucleophilic substitutions, and as a building block for advanced materials.

Our product is rigorously tested for purity (≥99%) and consistency, ensuring optimal performance in demanding laboratory and industrial applications. Supplied in sealed, light-resistant containers to maintain stability, it is ideal for researchers requiring precise and reliable reagents for fluorinated compound synthesis, medicinal chemistry, or material science.

Properties

• CAS Number: 407-14-7
• Complexity: 140
• IUPAC Name: 1-bromo-4-(trifluoromethoxy)benzene
• InChI: InChI=1S/C7H4BrF3O/c8-5-1-3-6(4-2-5)12-7(9,10)11/h1-4H
• InChI Key: SEAOBYFQWJFORM-UHFFFAOYSA-N
• Exact Mass: 239.93976
• Molecular Formula: C7H4BrF3O
• Molecular Weight: 241.00
• SMILES: C1=CC(=CC=C1OC(F)(F)F)Br
• Topological: 9.2
• Monoisotopic Mass: 239.93976
• Synonyms: 1-Bromo-4-(trifluoromethoxy)benzene, 407-14-7, EINECS 206-979-2, DTXSID90193672, DTXCID30116163, 206-979-2, 4-(Trifluoromethoxy)bromobenzene, 4-Bromo(trifluoromethoxy)benzene, 4-trifluoromethoxybromobenzene, Benzene, 1-bromo-4-(trifluoromethoxy)-, p-bromotrifluoromethoxybenzene, MFCD00040834, 4-bromo-1-(trifluoromethoxy)benzene, 1-bromo-4-trifluoromethoxy-benzene, p-trifluoromethoxybromobenzene, 4-bromotrifluoromethoxybenzene, 4-bromo-trifluoromethoxybenzene, 4-trifluoromethoxy-1-bromobenzene, p-Bromophenyl trifluoromethyl ether, 4-trifluoromethoxyphenyl bromide, P-Bromotrifluoromethoxybenzen, AD5CH69MK6, SCHEMBL220074, SCHEMBL457142, SCHEMBL457425, 4-trifluoromethoxy bromobenzene, 4-trifluoromethoxy-bromobenzene, trifluoromethoxy-4-bromobenzene, 4-trifluoromethyloxybromobenzene, 4-(trifluromethoxy)bromobenzene, 4-trifluoromethoxy bromo benzene, 1-bromo-4-trifluoromethoxybenzene, 4-(trifluoromethoxy)phenyl bromide, 1-bromo4-(trifluoromethoxy)benzene, 4-bromo-(trifluoromethoxy)-benzene, SBB006606, 1-bromo-4-(trifluoro-methoxy)benzene, 1-bromo-4-(trifluoromethoxy)-benzene, AKOS000176204, CS-W010286, PS-7577, SB66809, 1-bromo-4-(trifluoromethyloxy)-benzene, AC-13391, 1-Bromo-4-(trifluoromethoxy)benzene, 99%, DB-024011, B1772, NS00043207, ST50306934, EN300-107648, F0001-2667, InChI=1/C7H4BrF3O/c8-5-1-3-6(4-2-5)12-7(9,10)11/h1-4

1-Bromo-4-(trifluoromethoxy)benzene is widely used as a key precursor in Suzuki-Miyaura and other palladium-catalyzed cross-coupling reactions to introduce trifluoromethoxy-substituted aryl groups. It serves as a versatile intermediate in pharmaceutical development, particularly for bioactive molecules with enhanced metabolic stability. Additionally, its electron-withdrawing properties make it valuable in agrochemical synthesis and advanced material design.

Safety and Hazards

GHS Hazard Statements

• H302 (70.9%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (83.6%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H334 (70.9%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]
• H335 (81.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P233, P260, P261, P264, P264+P265, P270, P271, P280, P284, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P342+P316, P362+P364, P403, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (70.9%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (83.6%)
• Resp. Sens. 1 (70.9%)
• STOT SE 3 (81.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.