Description

2-Bromo-5-chloropyridine (CAS No. 40473-01-6) is a high-purity halogenated pyridine derivative widely used in pharmaceutical, agrochemical, and materials science research. With the molecular formula C₅H₃BrClN, this compound serves as a versatile building block for heterocyclic synthesis, particularly in cross-coupling reactions such as Suzuki, Stille, and Buchwald-Hartwig amination. Its unique structure enables precise functionalization, making it invaluable for developing active pharmaceutical ingredients (APIs) and advanced organic materials. Available in >98% purity, our product is rigorously tested via GC, HPLC, and NMR to ensure consistency for sensitive applications. Suitable for lab-scale and industrial use, it is supplied in secure, light-resistant packaging with detailed analytical certificates.

Properties

• CAS Number: 40473-01-6
• Complexity: 78.8
• IUPAC Name: 2-bromo-5-chloro-pyridine
• InChI: InChI=1S/C5H3BrClN/c6-5-2-1-4(7)3-8-5/h1-3H
• InChI Key: BZUUVQCSPHPUQA-UHFFFAOYSA-N
• Exact Mass: 190.91374
• Molecular Formula: C5H3BrClN
• Molecular Weight: 192.44
• SMILES: C1=CC(=NC=C1Cl)Br
• Topological: 12.9
• Monoisotopic Mass: 190.91374
• Synonyms: 2-Bromo-5-chloropyridine, 40473-01-6, BZUUVQCSPHPUQA-UHFFFAOYSA-, DTXSID60355740, DTXCID80306799, 668-305-7, inchi=1/c5h3brcln/c6-5-2-1-4(7)3-8-5/h1-3h, MFCD00234006, AC-3174, 2-Bromo-5-chloro-pyridine, Pyridine, 2-bromo-5-chloro-, 5-chloro-2-bromopyridine, SCHEMBL132151, SCHEMBL2687101, 2-bromanyl-5-chloranyl-pyridine, BCP22190, SBB054397, AKOS000431701, AB05069, CS-W002545, FB64674, FG-0472, SY004233, DB-005202, B2763, EN300-50142, A825122, AC-907/25004332, Z415645024

2-Bromo-5-chloropyridine is extensively employed as a key intermediate in synthesizing biologically active compounds, including kinase inhibitors and antiviral agents. Its reactivity facilitates selective modifications at the 2- and 5-positions, enabling the creation of complex pharmacophores. Researchers also utilize it in material science for constructing conjugated polymers with tailored electronic properties. The compound’s stability under diverse reaction conditions makes it ideal for multistep synthetic routes.

Safety and Hazards

GHS Hazard Statements

• H301 (92.9%): Toxic if swallowed [Danger Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (92.9%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H335 (97.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P330, P332+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (92.9%)
• Skin Irrit. 2 (100%)
• Eye Dam. 1 (92.9%)
• STOT SE 3 (97.6%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.