Description

2-Bromo-1-(4-fluorophenyl)ethan-1-one (CAS No. 403-29-2) is a high-purity brominated aromatic ketone with the molecular formula C₈H₆BrFO. This compound is widely utilized as a key intermediate in organic synthesis, particularly in the preparation of pharmaceuticals, agrochemicals, and specialty materials. Its structural features, including the reactive bromoacetyl group and the electron-withdrawing fluorine substituent, make it a versatile building block for nucleophilic substitution reactions, cyclizations, and cross-coupling methodologies.

Available in >98% purity (GC), this product is rigorously tested to ensure consistency and reliability for research and industrial applications. Proper storage under inert conditions is recommended to maintain stability. Suitable for use in medicinal chemistry, material science, and as a precursor for heterocyclic compounds.

Properties

• CAS Number: 403-29-2
• Complexity: 141
• IUPAC Name: 2-bromo-1-(4-fluorophenyl)ethanone
• InChI: InChI=1S/C8H6BrFO/c9-5-8(11)6-1-3-7(10)4-2-6/h1-4H,5H2
• InChI Key: ZJFWCELATJMDNO-UHFFFAOYSA-N
• Exact Mass: 215.95861
• Molecular Formula: C8H6BrFO
• Molecular Weight: 217.03
• SMILES: C1=CC(=CC=C1C(=O)CBr)F
• Topological: 17.1
• Monoisotopic Mass: 215.95861
• Synonyms: 2-Bromo-1-(4-fluorophenyl)ethan-1-one, EINECS 206-955-1, DTXSID20193307, NSC 88343, DTXCID90115798, 206-955-1, 403-29-2, 2-Bromo-4′-fluoroacetophenone, 2-Bromo-1-(4-fluorophenyl)ethanone, 4-Fluorophenacyl bromide, p-Fluorophenacyl bromide, Ethanone, 2-bromo-1-(4-fluorophenyl)-, 4-fluorophenacylbromide, MFCD00040830, Bromo-4-fluoroacetophenone, N3PVV2GVQ8, CHEMBL317046, Acetophenone, 2-bromo-4′-fluoro-, 2-BroMo-4′-fluoroacetophenone–d4, NSC-88343, 2-Bromo-1-(4-fluoro-phenyl)-ethanone, ALPHA-BROMO-4-FLUOROACETOPHENONE, 4′-fluoro-2-bromoacetophenone, omega-Bromo-4-fluoroacetophenone, p-fluorophenacylbromide, UNII-N3PVV2GVQ8, a-bromo-4-fluoroacetophenone, 2-bromo-4’fluoroacetophenone, 2-bromo4′-fluoroacetophenone, SCHEMBL120278, 2-bromo-4′ fluoroacetophenone, 2-bromo-4′-fluoro-acetophenone, 2-bromo-4′-fluoroaceto-phenone, 2-Bromo-4′-fluoroacetophenone, .omega.-Bromo-4-fluoroacetophenone, ALBB-037316, NSC88343, 2-bromo-(4-fluoro-phenyl) ethanone, BDBM50119681, SBB006561, STK208492, 2-Bromo-1-(4-fluoro-phenyl)ethanone, 2-bromo-1-(4-fluorophenyl) ethanone, 2-bromo-1-(4-fluorophenyl)-ethanone, 2-Bromo-4′-fluoroacetophenone, 97%, AKOS000210841, CS-W009314, 2-Bromo-1-(4-fluorophenyl)ethanone #, 2-bromo-1-(4-fluorophenyl)ethane-1-one, AC-14103, BP-20114, PD140507, 2-bromo-1-(4-fluorophenyl) ethan-1-one, DB-010960, B2382, NS00043264, ST50214002, EN300-21388, F0001-1141, Z104495742, InChI=1/C8H6BrFO/c9-5-8(11)6-1-3-7(10)4-2-6/h1-4H,5H

Application

2-Bromo-1-(4-fluorophenyl)ethan-1-one serves as a critical synthon in the synthesis of fluorinated bioactive molecules, including kinase inhibitors and antimicrobial agents. It is employed in Friedel-Crafts acylations and as a precursor for benzofuran derivatives. Researchers also utilize this compound in the development of fluorescent probes and liquid crystal materials due to its aromatic fluorophore-like properties.

Safety and Hazards

GHS Hazard Statements

• H314 (91.7%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

Precautionary Statements

• P260, P264, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P363, P405, and P501

Hazard Classes and Categories

• Skin Corr. 1C (91.7%)

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