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Atomfair Ethyl 4,6-dichloropyridine-3-carboxylate C8H7Cl2NO2 CAS 40296-46-6

Ethyl 4,6-dichloropyridine-3-carboxylate (CAS No. 40296-46-6) is a high-purity organic compound with the molecular formula C8H7Cl2NO2. This versatile intermediate features a pyridine core substituted with two chlorine atoms and an ethyl ester group, making it a valuable building block in pharmaceutical, agrochemical, and materials science research. With a molecular weight of 220.05 g/mol , this white to off-white crystalline powder offers excellent solubility in common organic solvents such as DMSO, methanol, and dichloromethane. Packaged under inert gas to ensure stability, our product meets stringent quality control standards with ≥98% purity (HPLC). Ideal for nucleophilic substitution reactions, cross-coupling reactions, and as a…

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Description

Ethyl 4,6-dichloropyridine-3-carboxylate (CAS No. 40296-46-6) is a high-purity organic compound with the molecular formula C8H7Cl2NO2. This versatile intermediate features a pyridine core substituted with two chlorine atoms and an ethyl ester group, making it a valuable building block in pharmaceutical, agrochemical, and materials science research. With a molecular weight of 220.05 g/mol, this white to off-white crystalline powder offers excellent solubility in common organic solvents such as DMSO, methanol, and dichloromethane. Packaged under inert gas to ensure stability, our product meets stringent quality control standards with ≥98% purity (HPLC). Ideal for nucleophilic substitution reactions, cross-coupling reactions, and as a precursor for heterocyclic compound synthesis.

Properties

  • CAS Number: 40296-46-6
  • Complexity: 189
  • IUPAC Name: ethyl 4,6-dichloropyridine-3-carboxylate
  • InChI: InChI=1S/C8H7Cl2NO2/c1-2-13-8(12)5-4-11-7(10)3-6(5)9/h3-4H,2H2,1H3
  • InChI Key: AAUBVINEXCCXOK-UHFFFAOYSA-N
  • Exact Mass: 218.9853839
  • Molecular Formula: C8H7Cl2NO2
  • Molecular Weight: 220.05
  • SMILES: CCOC(=O)C1=CN=C(C=C1Cl)Cl
  • Topological: 39.2
  • Monoisotopic Mass: 218.9853839
  • Synonyms: ethyl 4,6-dichloropyridine-3-carboxylate, 803-915-0, Ethyl 4,6-dichloronicotinate, 40296-46-6, 4,6-Dichloronicotinic acid ethyl ester, 4,6-Dichloropyridine-3-carboxylic acid ethyl ester, MFCD00234408, 4,6-dichloro-nicotinic acid ethyl ester, 2,4-dichloro-5-carbethoxypyridine, ETHYL 2,4-DICHLOROPYRIDINE-5-CARBOXYLATE, Ethyl4,6-DiChloronicotinate, 3-PYRIDINECARBOXYLIC ACID, 4,6-DICHLORO-, ETHYL ESTER, 4,6-dichloro-3-pyridinecarboxylic acid ethyl ester, SCHEMBL190973, Ethyl 4,6-dichloronicotinate #, DTXSID40344874, BCP14730, BBL101247, SBB062779, STL555043, AKOS005071556, AB-0727, AB05228, AC-5948, CS-W002558, FE33985, HY-W002558, SY008961, DB-025240, E1068, EN300-91595, 4,6-dichloropyridine-3-carboxylic acid ethylester, AC-907/25004777, Pyridine-3-carboxylic acid, 4,6-dichloro-, ethyl ester, Z1262255699

Ethyl 4,6-dichloropyridine-3-carboxylate serves as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of antiviral and antibacterial agents. Researchers utilize this compound for constructing complex pyridine derivatives via Suzuki-Miyaura or Buchwald-Hartwig couplings. In agrochemical applications, it acts as a precursor for crop protection chemicals. The dichloro substitution pattern enables selective functionalization at either the 4- or 6-position, offering synthetic flexibility for structure-activity relationship studies.

Safety and Hazards

GHS Hazard Statements

  • H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H335 (97.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Skin Irrit. 2 (100%)
  • Eye Irrit. 2A (100%)
  • STOT SE 3 (97.6%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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