Description

Difluoroacetic Anhydride (CAS No. 401-67-2) is a highly reactive and versatile fluorinated organic compound with the molecular formula C₄H₂F₄O₃. This anhydride is widely used as a key reagent in organic synthesis, particularly for introducing difluoroacetyl groups into target molecules. Its exceptional reactivity makes it ideal for applications in pharmaceuticals, agrochemicals, and specialty materials. The compound is supplied as a clear, colorless liquid with high purity (>98%) to ensure optimal performance in demanding laboratory and industrial processes. Store under inert conditions to prevent hydrolysis and degradation.

Key Features:

• High reactivity for efficient difluoroacylation reactions
• Excellent purity grade for consistent results
• Wide compatibility with various organic substrates
• Strict quality control to meet research and industrial standards

Properties

• CAS Number: 401-67-2
• Complexity: 149
• IUPAC Name: (2,2-difluoroacetyl) 2,2-difluoroacetate
• InChI: InChI=1S/C4H2F4O3/c5-1(6)3(9)11-4(10)2(7)8/h1-2H
• InChI Key: IYXUFOCLMOXQSL-UHFFFAOYSA-N
• Exact Mass: 173.99400657
• Molecular Formula: C4H2F4O3
• Molecular Weight: 174.05
• SMILES: C(C(=O)OC(=O)C(F)F)(F)F
• Topological: 43.4
• Monoisotopic Mass: 173.99400657
• Synonyms: Difluoroacetic anhydride, 401-67-2, DTXSID90378861, DTXCID40329888, 674-863-2, (2,2-difluoroacetyl) 2,2-difluoroacetate, 2,2-difluoroacetyl 2,2-difluoroacetate, MFCD02093315, 1,1,5,5-Tetrafluoro-3-oxapentan-2,4-dione, Acetic acid, difluoro-, anhydride, DIFLUOROACETICANHYDRIDE, C4H2F4O3, difluoroactic anhydride, difluoroacetic acid anhydride, 2,2-difluoroacetic anhydride, SCHEMBL308254, SBB051386, AKOS005169317, MS-20468, 2,2-Difluoro-acetic acid 1,1′-anhydride, CS-0121251, D4164, EN300-105552, F14887

Difluoroacetic anhydride serves as a crucial reagent for introducing difluoroacetyl functional groups in synthetic organic chemistry. It is extensively used in pharmaceutical research for the modification of active pharmaceutical ingredients (APIs) and in agrochemical development for creating novel pesticide derivatives. The compound also finds application in materials science for synthesizing fluorinated polymers with enhanced properties. Its reactivity makes it valuable for peptide modification and specialty chemical synthesis.

Safety and Hazards

GHS Hazard Statements

• H225 (22.2%): Highly Flammable liquid and vapor [Danger Flammable liquids]
• H290 (11.1%): May be corrosive to metals [Warning Corrosive to Metals]
• H302 (11.1%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (11.1%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H318 (33.3%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H332 (44.4%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (22.2%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H412 (11.1%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P210, P233, P234, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P319, P321, P330, P362+P364, P363, P370+P378, P390, P403+P233, P403+P235, P405, P406, and P501

Hazard Classes and Categories

• Flam. Liq. 2 (22.2%)
• Met. Corr. 1 (11.1%)
• Acute Tox. 4 (11.1%)
• Acute Tox. 4 (11.1%)
• Skin Corr. 1B (100%)
• Eye Dam. 1 (33.3%)
• Acute Tox. 4 (44.4%)
• STOT SE 3 (22.2%)
• Aquatic Chronic 3 (11.1%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.