Description

2-Acetyl-4-fluorophenol (CAS No. 394-32-1) is a high-purity fluorinated aromatic compound with the molecular formula C₈H₇FO₂. This fine chemical, also known by its IUPAC name 1-(5-fluoro-2-hydroxyphenyl)ethanone, features a unique combination of acetyl and hydroxyl functional groups on a fluorinated benzene ring, making it a valuable intermediate in organic synthesis and pharmaceutical research. The compound is supplied as a crystalline solid with ≥98% purity (HPLC), ideal for precision applications. Its structural properties enable versatile reactivity in electrophilic aromatic substitution and carbonyl chemistry. Proper storage at 2-8°C in a tightly sealed container under inert atmosphere is recommended to maintain stability. Suitable for research and industrial use only – not for drug or household applications.

Properties

• CAS Number: 394-32-1
• Complexity: 158
• IUPAC Name: 1-(5-fluoro-2-hydroxy-phenyl)ethanone
• InChI: InChI=1S/C8H7FO2/c1-5(10)7-4-6(9)2-3-8(7)11/h2-4,11H,1H3
• InChI Key: KOFFXZYMDLWRHX-UHFFFAOYSA-N
• Exact Mass: 154.04300762
• Molecular Formula: C8H7FO2
• Molecular Weight: 154.14
• SMILES: CC(=O)C1=C(C=CC(=C1)F)O
• Topological: 37.3
• Monoisotopic Mass: 154.04300762
• Synonyms: 394-32-1, 5′-Fluoro-2′-hydroxyacetophenone, 1-(5-Fluoro-2-hydroxyphenyl)ethanone, 1-(5-Fluoro-2-hydroxyphenyl)ethan-1-one, 5-Fluoro-2-hydroxyacetophenone, 2-Hydroxy-5-fluoroacetophenone, Acetophenone, 5′-fluoro-2′-hydroxy-, 2-Acetyl-4-fluorophenol, UE6FHC9K7M, NSC-46624, KOFFXZYMDLWRHX-UHFFFAOYSA-, DTXSID30192588, NSC 46624, DTXCID70115079, 3-FLUORO-6-HYDROXYACETOPHENONE, inchi=1/c8h7fo2/c1-5(10)7-4-6(9)2-3-8(7)11/h2-4,11h,1h3, koffxzymdlwrhx-uhfffaoysa-n, 1-(5-fluoro-2-hydroxyphenyl)-1-ethanone, Ethanone, 1-(5-fluoro-2-hydroxyphenyl)-, 2′-hydroxy-5′-fluoroacetophenone, MFCD00011668, 1-acetyl-5-fluoro-2-hydroxybenzene, 5′-Fluoro-2′-hydroxy-acetophenone, EINECS 206-893-5, 1-(2-hydroxy-5-fluorophenyl)ethanone, BRN 2359087, NSC46624, 1-(5-fluoro-2-hydroxy-phenyl)ethanone, UNII-UE6FHC9K7M, 4-08-00-00325 (Beilstein Handbook Reference), SCHEMBL467241, SCHEMBL9031988, 5-fluoro-2-hydroxy acetophenone, 5-fluoro-2-hydroxy-acetophenone, CHEMBL5278222, 5-hydroxyacetophenone, CHEBI:194799, ALBB-017940, BCP32561, CK2583, SBB063131, STK507083, 1-(5-luoro-2-hydroxyphenyl)ethanone, AKOS001052571, AC-2767, CS-W007851, 1-(5-fluoro-2-hydroxyphenyl) ethanone, 5 inverted exclamation mark -Fluoro-2 inverted exclamation mark -hydroxyacetophenone, 5′-Fluoro-2′-hydroxyacetophenone, 98%, 1-(5-Fluoro-2-hydroxy-phenyl)-ethanone, 1-(5-Fluoro-2-hydroxyphenyl)ethanone #, BP-13406, SY002859, F0318, NS00042720, ST50331353, EN300-17016, 6C-009, Z56858268, 2-Acetyl-4-fluorophenol;1-(5-Fluoro-2-hydroxyphenyl)ethanone

Application

2-Acetyl-4-fluorophenol serves as a key building block in pharmaceutical synthesis, particularly for fluorinated drug candidates targeting CNS disorders. Its phenolic hydroxyl group allows for easy derivatization into ethers or esters, while the acetyl moiety participates in condensation reactions. Researchers utilize this compound in the development of novel fluorinated chalcones and benzofuran derivatives with potential biological activity. The fluorine substitution enhances metabolic stability in medicinal chemistry applications.

Safety and Hazards

GHS Hazard Statements

• H302 (88%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (98%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (88%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (98%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.