Description

4-Fluoro-2-(trifluoromethyl)aniline (CAS No. 393-39-5) is a high-purity fluorinated aromatic amine with the molecular formula C₇H₅F₄N. This compound, also known by its IUPAC name 4-fluoro-2-(trifluoromethyl)aniline, is a versatile building block in organic synthesis and pharmaceutical research. Its unique structure, featuring both fluorine and trifluoromethyl substituents, enhances electron-withdrawing properties, making it valuable for designing advanced materials and bioactive molecules.

Our product is rigorously tested to ensure ≥98% purity (GC) and is supplied as a clear to pale yellow liquid. It is packaged under inert gas to maintain stability and is ideal for use in nucleophilic substitutions, cross-coupling reactions, and as a precursor for agrochemicals or pharmaceuticals. Store in a cool, dry place away from light and oxidizing agents.

Synonyms: 2-Amino-5-fluorobenzotrifluoride, Benzenamine, 4-fluoro-2-(trifluoromethyl)-, alpha,alpha,alpha,4-Tetrafluoro-o-toluidine

Properties

• CAS Number: 393-39-5
• Complexity: 156
• IUPAC Name: 4-fluoro-2-(trifluoromethyl)aniline
• InChI: InChI=1S/C7H5F4N/c8-4-1-2-6(12)5(3-4)7(9,10)11/h1-3H,12H2
• InChI Key: LRCQLCWUUBSUOY-UHFFFAOYSA-N
• Exact Mass: 179.03581181
• Molecular Formula: C7H5F4N
• Molecular Weight: 179.11
• SMILES: C1=CC(=C(C=C1F)C(F)(F)F)N
• Topological: 26
• Monoisotopic Mass: 179.03581181
• Synonyms: 2-Amino-5-fluorobenzotrifluoride, 393-39-5, 4-Fluoro-2-(trifluoromethyl)aniline, Benzenamine, 4-fluoro-2-(trifluoromethyl)-, alpha,alpha,alpha,4-Tetrafluoro-o-toluidine, 4-Fluoro-2-trifluoromethyl-phenylamine, 4-Fluoro-2-trifluoromethylaniline, MFCD00007831, NSC-10325, EN300-68231, 4-fluoro-2-(trifluoromethyl)phenylamine, alpha,alpha,alpha-4-Tetrafluoro-o-toluidine, EINECS 206-886-7, NSC10325, SCHEMBL185520, T5T8A7TV37, DTXSID9022029, 2-trifluoromethyl-4-fluoraniline, LRCQLCWUUBSUOY-UHFFFAOYSA-, 2-trifluoromethyl-4-fluoroaniline, CHEBI:230764, UOUBPXYUWQGKTK-UHFFFAOYSA-N, 4-luoro-2-(triluoromethyl)aniline, BDBM626202, 2-trifluoromethyl- 4-fluoroaniline, 2-trifluoromethyl-4-fluoro-aniline, 4-fluoro-2-trifluoromethyl-aniline, 2-(Trifluoromethyl)-4-fluoroaniline, NSC 10325, SBB028386, 4-fluoro-2-(trifluoromethyl)-aniline, AKOS006221183, AC-6876, CS-W017288, PS-8552, 4-Fluoro-2-(trifluoromethyl)benzenamine, BP-11269, 4-Fluoro-2-(trifluoromethyl)aniline, 99%, A1158, alpha,alpha,alpha,4-Tetrafluoro-2-toluidine, NS00043681, ST50406512, alpha,alpha,alpha,4-Tetrafluoro-2-methylaniline, .alpha.,.alpha.,.alpha.,4-Tetrafluoro-o-toluidine, o-Toluidine, .alpha.,.alpha.,.alpha.,4-tetrafluoro-, 2-Amino-5-fluorobenzotrifluoride;4-fluoro-2-trifluoromethylaniline, InChI=1/C7H5F4N/c8-4-1-2-6(12)5(3-4)7(9,10)11/h1-3H,12H2

Application

4-Fluoro-2-(trifluoromethyl)aniline is widely used as an intermediate in the synthesis of fluorinated pharmaceuticals, agrochemicals, and liquid crystals. Its electron-deficient aromatic ring facilitates reactions such as Buchwald-Hartwig amination or Suzuki-Miyaura coupling. Researchers employ it to develop kinase inhibitors, herbicides, and OLED materials due to its enhanced lipophilicity and metabolic stability. Handle with standard aryl amine precautions under fume hoods.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (91.7%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (89.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Acute Tox. 4 (91.7%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (100%)
• STOT SE 3 (89.6%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.