Description

6-(Trifluoromethyl)pyridine-3-methanol (CAS No. 386704-04-7) is a high-purity fluorinated pyridine derivative with the molecular formula C₇H₆F₃NO. This compound, also known by its IUPAC name [6-(trifluoromethyl)pyridin-3-yl]methanol, is a versatile building block in pharmaceutical and agrochemical synthesis. Its unique trifluoromethyl group enhances lipophilicity and metabolic stability, making it valuable for drug discovery. Available in >98% purity (HPLC), this white to off-white crystalline powder is packaged under inert gas to ensure stability. Suitable for nucleophilic substitutions, cross-coupling reactions, and as a precursor for chiral ligands. Ships with MSDS, analytical certificates, and optional NMR/LCMS data.

Properties

• CAS Number: 386704-04-7
• Complexity: 148
• IUPAC Name: [6-(trifluoromethyl)-3-pyridyl]methanol
• InChI: InChI=1S/C7H6F3NO/c8-7(9,10)6-2-1-5(4-12)3-11-6/h1-3,12H,4H2
• InChI Key: CBSXUFWMVOAHTK-UHFFFAOYSA-N
• Exact Mass: 177.04014830
• Molecular Formula: C7H6F3NO
• Molecular Weight: 177.12
• SMILES: C1=CC(=NC=C1CO)C(F)(F)F
• Topological: 33.1
• Monoisotopic Mass: 177.04014830
• Synonyms: 386704-04-7, 6-(Trifluoromethyl)pyridine-3-methanol, DTXSID30394247, DTXCID20345107, 626-601-3, (6-(trifluoromethyl)pyridin-3-yl)methanol, [6-(trifluoromethyl)pyridin-3-yl]methanol, [6-(Trifluoromethyl)-3-pyridyl]methanol, MFCD01862648, 2-(trifluoromethyl)pyridine-5-methanol, 5-(hydroxymethyl)-2-(trifluoromethyl)pyridine, 3-Pyridinemethanol,6-(trifluoromethyl)-, 6-(trifluoromethyl)pyridin-3-methanol, 3-Pyridinemethanol, 6-(trifluoromethyl)-, (6-trifluoromethyl-pyridin-3-yl)-methanol, 3-hydroxymethyl-6-trifluoromethylpyridine, SCHEMBL132198, SCHEMBL452178, 6-trifluoromethyl-3-pyridylmethanol, BCP12642, SBB054790, AKOS005073285, AC-2755, LB-0702, SB53492, (6-trifluoromethylpyridin-3-yl)-methanol, SY002813, [6-(trifluoromethyl)-3-pyridinyl]methanol, (6-(trifluoromethyl)pyridin-3-y1)methanol, [6-(trifluoromethyl)pyridine-3-yl]methanol, [6-(trifluoromethyl)-3-pyridyl]methan-1-ol, CS-0084388, T3927, 6-(Trifluoromethyl)pyridine-3-methanol, 97%, EN300-314497, [6-(Trifluoromethyl)pyridin-3-yl]methanol, 6-(Trifluoromethyl)nicotinyl alcohol

Application

6-(Trifluoromethyl)pyridine-3-methanol serves as a key intermediate in the synthesis of trifluoromethylated pharmaceuticals, particularly kinase inhibitors and CNS-active compounds. The trifluoromethyl group improves bioavailability and binding affinity in drug candidates. Researchers utilize this compound to develop novel agrochemicals with enhanced pest resistance properties. Its hydroxyl functionality allows for further derivatization in medicinal chemistry applications.

Safety and Hazards

GHS Hazard Statements

• H301 (93.5%): Toxic if swallowed [Danger Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H317 (93.5%): May cause an allergic skin reaction [Warning Sensitization, Skin]
• H318 (93.5%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H335 (97.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P272, P280, P301+P316, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P330, P332+P317, P333+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (93.5%)
• Skin Irrit. 2 (100%)
• Skin Sens. 1 (93.5%)
• Eye Dam. 1 (93.5%)
• STOT SE 3 (97.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.