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Atomfair 2-Chloro-5-fluoro-3-methylpyridine C6H5ClFN CAS 38186-84-4

2-Chloro-5-fluoro-3-methylpyridine (CAS No. 38186-84-4) is a high-purity halogenated pyridine derivative with the molecular formula C6H5ClFN . This heterocyclic compound features a chloro- and fluoro-substituted pyridine ring with a methyl group at the 3-position, making it a versatile intermediate for pharmaceutical and agrochemical synthesis. Available in >98% purity (GC), this crystalline solid (melting point 45-48°C) is packaged under inert gas to ensure stability. Suitable for nucleophilic substitution reactions, metal-catalyzed cross-couplings, and as a building block for bioactive molecules. Shipped with MSDS, NMR, and HPLC analytical data. Store in cool, dry conditions away from strong oxidizers.

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Description

2-Chloro-5-fluoro-3-methylpyridine (CAS No. 38186-84-4) is a high-purity halogenated pyridine derivative with the molecular formula C6H5ClFN. This heterocyclic compound features a chloro- and fluoro-substituted pyridine ring with a methyl group at the 3-position, making it a versatile intermediate for pharmaceutical and agrochemical synthesis. Available in >98% purity (GC), this crystalline solid (melting point 45-48°C) is packaged under inert gas to ensure stability. Suitable for nucleophilic substitution reactions, metal-catalyzed cross-couplings, and as a building block for bioactive molecules. Shipped with MSDS, NMR, and HPLC analytical data. Store in cool, dry conditions away from strong oxidizers.

Properties

  • CAS Number: 38186-84-4
  • Complexity: 99.1
  • IUPAC Name: 2-chloro-5-fluoro-3-methyl-pyridine
  • InChI: InChI=1S/C6H5ClFN/c1-4-2-5(8)3-9-6(4)7/h2-3H,1H3
  • InChI Key: FMPYGEFGXUAAKG-UHFFFAOYSA-N
  • Exact Mass: 145.0094550
  • Molecular Formula: C6H5ClFN
  • Molecular Weight: 145.56
  • SMILES: CC1=CC(=CN=C1Cl)F
  • Topological: 12.9
  • Monoisotopic Mass: 145.0094550
  • Synonyms: 2-Chloro-5-fluoro-3-methylpyridine, 38186-84-4, DTXSID70511471, DTXCID30462278, 692-489-8, 2-Chloro-5-fluoro-3-picoline, MFCD04972725, 2-Chloro-5-fluoro-3-methyl-pyridine, PYRIDINE, 2-CHLORO-5-FLUORO-3-METHYL-, SCHEMBL1853177, SCHEMBL20298348, SCHEMBL27808114, FMPYGEFGXUAAKG-UHFFFAOYSA-N, 5-fluoro-2-chloro-3-methylpyridine, BBL101358, SBB086440, STL555154, AKOS005063608, AB21234, AC-1510, CS-W003216, PS-8951, SY023651, DB-023666, C3144, EN300-88327

Application

This compound serves as a key precursor in the synthesis of crop protection agents, particularly fungicides and herbicides targeting cereal diseases. Pharmaceutical researchers utilize it to develop kinase inhibitors and CNS-active compounds due to its balanced lipophilicity (LogP ~2.1). The orthogonal halogen substitution pattern enables sequential functionalization via Suzuki-Miyaura coupling (chloro) and nucleophilic aromatic substitution (fluoro).

Safety and Hazards

GHS Hazard Statements

  • H302 (66.7%): Harmful if swallowed [Warning Acute toxicity, oral]
  • H312 (33.3%): Harmful in contact with skin [Warning Acute toxicity, dermal]
  • H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H332 (33.3%): Harmful if inhaled [Warning Acute toxicity, inhalation]
  • H335 (66.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Acute Tox. 4 (66.7%)
  • Acute Tox. 4 (33.3%)
  • Skin Irrit. 2 (100%)
  • Eye Irrit. 2A (100%)
  • Acute Tox. 4 (33.3%)
  • STOT SE 3 (66.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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