Description

2-Chloro-5-fluoro-3-methylpyridine (CAS No. 38186-84-4) is a high-purity halogenated pyridine derivative with the molecular formula C₆H₅ClFN. This heterocyclic compound features a chloro- and fluoro-substituted pyridine ring with a methyl group at the 3-position, making it a versatile intermediate for pharmaceutical and agrochemical synthesis. Available in >98% purity (GC), this crystalline solid (melting point 45-48°C) is packaged under inert gas to ensure stability. Suitable for nucleophilic substitution reactions, metal-catalyzed cross-couplings, and as a building block for bioactive molecules. Shipped with MSDS, NMR, and HPLC analytical data. Store in cool, dry conditions away from strong oxidizers.

Properties

• CAS Number: 38186-84-4
• Complexity: 99.1
• IUPAC Name: 2-chloro-5-fluoro-3-methyl-pyridine
• InChI: InChI=1S/C6H5ClFN/c1-4-2-5(8)3-9-6(4)7/h2-3H,1H3
• InChI Key: FMPYGEFGXUAAKG-UHFFFAOYSA-N
• Exact Mass: 145.0094550
• Molecular Formula: C6H5ClFN
• Molecular Weight: 145.56
• SMILES: CC1=CC(=CN=C1Cl)F
• Topological: 12.9
• Monoisotopic Mass: 145.0094550
• Synonyms: 2-Chloro-5-fluoro-3-methylpyridine, 38186-84-4, DTXSID70511471, DTXCID30462278, 692-489-8, 2-Chloro-5-fluoro-3-picoline, MFCD04972725, 2-Chloro-5-fluoro-3-methyl-pyridine, PYRIDINE, 2-CHLORO-5-FLUORO-3-METHYL-, SCHEMBL1853177, SCHEMBL20298348, SCHEMBL27808114, FMPYGEFGXUAAKG-UHFFFAOYSA-N, 5-fluoro-2-chloro-3-methylpyridine, BBL101358, SBB086440, STL555154, AKOS005063608, AB21234, AC-1510, CS-W003216, PS-8951, SY023651, DB-023666, C3144, EN300-88327

Application

This compound serves as a key precursor in the synthesis of crop protection agents, particularly fungicides and herbicides targeting cereal diseases. Pharmaceutical researchers utilize it to develop kinase inhibitors and CNS-active compounds due to its balanced lipophilicity (LogP ~2.1). The orthogonal halogen substitution pattern enables sequential functionalization via Suzuki-Miyaura coupling (chloro) and nucleophilic aromatic substitution (fluoro).

Safety and Hazards

GHS Hazard Statements

• H302 (66.7%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (33.3%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (33.3%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (66.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (66.7%)
• Acute Tox. 4 (33.3%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• Acute Tox. 4 (33.3%)
• STOT SE 3 (66.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.