Description

5-Amino-2-bromo-3-methylpyridine (CAS No. 38186-83-3) is a high-purity heterocyclic compound with the molecular formula C₆H₇BrN₂. This versatile chemical intermediate is widely used in pharmaceutical synthesis, agrochemical research, and materials science. The compound features a pyridine ring substituted with an amino group at the 5-position, a bromo group at the 2-position, and a methyl group at the 3-position, making it a valuable building block for nucleophilic aromatic substitution and cross-coupling reactions.

Our product is synthesized under strict quality control measures, ensuring ≥98% purity (HPLC) with minimal impurities. It is supplied as a white to off-white crystalline powder with excellent batch-to-batch consistency. Proper storage in a cool, dry place (2-8°C) under inert atmosphere is recommended to maintain stability.

Key applications include:

• Pharmaceutical intermediate for API development
• Ligand precursor in catalytic systems
• Building block for functional materials

Available in research quantities (100mg-1g) to bulk scales (1kg+), packaged in amber glass vials or double-sealed foil bags under nitrogen atmosphere for maximum stability. Technical data sheets and certificates of analysis are provided with every shipment.

Properties

• CAS Number: 38186-83-3
• Complexity: 97.1
• IUPAC Name: 6-bromo-5-methyl-pyridin-3-amine
• InChI: InChI=1S/C6H7BrN2/c1-4-2-5(8)3-9-6(4)7/h2-3H,8H2,1H3
• InChI Key: IEONGQZSAUAAKH-UHFFFAOYSA-N
• Exact Mass: 185.97926
• Molecular Formula: C6H7BrN2
• Molecular Weight: 187.04
• SMILES: CC1=CC(=CN=C1Br)N
• Topological: 38.9
• Monoisotopic Mass: 185.97926
• Synonyms: 5-Amino-2-bromo-3-methylpyridine, 833-076-6, 5-Amino-2-bromo-3-picoline, 38186-83-3, 6-bromo-5-methylpyridin-3-amine, MFCD03095085, EN300-131929, 3-Pyridinamine, 6-bromo-5-methyl-, SCHEMBL2407304, DTXSID00494243, IEONGQZSAUAAKH-UHFFFAOYSA-N, 2-bromo-5-amino-3-methylpyridine, BDBM626016, CS-D0970, BBL101265, STL555061, AKOS005257957, AB13464, DS-0481, SB40595, AC-23438, SY024695, DB-006935, A2975, 5-Amino-2-bromo-3-picoline (5-Amino-2-bromo-3-methylpyridine)

5-Amino-2-bromo-3-methylpyridine serves as a key intermediate in the synthesis of pharmaceutical compounds, particularly in the development of kinase inhibitors and antiviral agents. The bromo substituent enables palladium-catalyzed cross-coupling reactions for structure diversification, while the amino group facilitates further functionalization. Researchers utilize this compound in medicinal chemistry for lead optimization and scaffold hopping strategies. Its unique substitution pattern also makes it valuable for creating chelating ligands in coordination chemistry.

Safety and Hazards

GHS Hazard Statements

• H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (50%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (50%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (50%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.