Description

Difluoroacetic Acid (CAS No. 381-73-7) is a high-purity fluorinated organic compound with the molecular formula C₂H₂F₂O₂ and IUPAC name 2,2-difluoroacetic acid. This versatile reagent is characterized by its strong acidity and the presence of two fluorine atoms, which enhance its reactivity and utility in synthetic chemistry. It is supplied as a clear, colorless liquid with a pungent odor, suitable for use in a wide range of laboratory and industrial applications. Our Difluoroacetic Acid is rigorously tested for purity and consistency, ensuring optimal performance in organic synthesis, pharmaceutical research, and material science. Proper handling is essential due to its corrosive nature—always use appropriate personal protective equipment (PPE) and storage conditions.

Properties

• CAS Number: 381-73-7
• Complexity: 60.6
• IUPAC Name: 2,2-difluoroacetic acid
• InChI: InChI=1S/C2H2F2O2/c3-1(4)2(5)6/h1H,(H,5,6)
• InChI Key: PBWZKZYHONABLN-UHFFFAOYSA-N
• Exact Mass: 96.00228563
• Molecular Formula: C2H2F2O2
• Molecular Weight: 96.03
• SMILES: C(C(=O)O)(F)F
• Topological: 37.3
• Monoisotopic Mass: 96.00228563
• Synonyms: DIFLUOROACETIC ACID, 381-73-7, Acetic acid, difluoro-, Difluoressigsaeure, UNII-ZQK1C95K3N, EINECS 206-839-0, ZQK1C95K3N, Acetic acid, 2,2-difluoro-, BRN 1098588, CHEBI:23716, AI3-28548, DTXSID2059932, EC 206-839-0, 4-02-00-00455 (Beilstein Handbook Reference), DTXCID5039430, 206-839-0, inchi=1/c2h2f2o2/c3-1(4)2(5)6/h1h,(h,5,6, pbwzkzyhonabln-uhfffaoysa-n, 2,2-Difluoroacetic acid, 1,1-difluoroacetic acid, C2H2F2O2, difluoracetic acid, Acetic acid, difluoro- (6CI,7CI,8CI,9CI); 2,2-Difluoroacetic acid; Difluoroacetic acid, Difluoro-acetic acid, MFCD00004220, Difluoroacetic acid, 98%, SCHEMBL104463, SCHEMBL246207, CHEMBL453969, SCHEMBL1156202, UMVBMCIAQFZUKB-UHFFFAOYSA-N, FD2068, STK260852, AKOS000118821, FD53770, BP-10757, PS-18111, DB-049243, CS-0015390, D1423, NS00003534, EN300-19507, Q15126139, Z104474070

Application

Difluoroacetic Acid is widely used as a building block in the synthesis of fluorinated pharmaceuticals, agrochemicals, and specialty materials. Its strong acidity and unique fluorine substitution make it valuable for introducing difluoroacetyl groups into target molecules. Researchers also employ it in the preparation of bioactive compounds and as a catalyst or reagent in organic transformations. Additionally, it serves as a precursor for the development of advanced materials with tailored properties.

Safety and Hazards

GHS Hazard Statements

• H227: Combustible liquid [Warning Flammable liquids]
• H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H402: Harmful to aquatic life [Hazardous to the aquatic environment, acute hazard]
• H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P210, P260, P264, P264+P265, P273, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P363, P370+P378, P391, P403, P405, and P501

Hazard Classes and Categories

• Flammable liquids – Category 4
• Skin corrosion/irritation – Category 1
• Serious eye damage/eye irritation – Category 1
• Hazardous to the aquatic environment – Category 3
• Hazardous to the aquatic environment – Category 1

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.