Description

2-Chloro-4-methylpyridine (CAS No. 3678-62-4) is a high-purity organic compound with the molecular formula C₆H₆ClN. This heterocyclic aromatic compound features a chlorine substituent at the 2-position and a methyl group at the 4-position of the pyridine ring, making it a versatile intermediate in pharmaceutical, agrochemical, and specialty chemical synthesis. Its precise molecular structure ensures excellent reactivity in nucleophilic substitution and coupling reactions. Available in >98% purity (GC), this compound is rigorously tested for quality, stability, and consistency, meeting the stringent requirements of research and industrial applications. Packaged under inert gas to prevent degradation, it is supplied in amber glass bottles or custom bulk quantities with full analytical documentation (COA, MSDS, NMR, HPLC).

Properties

• CAS Number: 3678-62-4
• Complexity: 74.9
• IUPAC Name: 2-chloro-4-methyl-pyridine
• InChI: InChI=1S/C6H6ClN/c1-5-2-3-8-6(7)4-5/h2-4H,1H3
• InChI Key: MZVSTDHRRYQFGI-UHFFFAOYSA-N
• Exact Mass: 127.0188769
• Molecular Formula: C6H6ClN
• Molecular Weight: 127.57
• SMILES: CC1=CC(=NC=C1)Cl
• Topological: 12.9
• Monoisotopic Mass: 127.0188769
• Synonyms: 2-Chloro-4-methylpyridine, 3678-62-4, EINECS 222-951-2, DTXSID30190241, DTXCID40112732, 222-951-2, 2-Chloro-4-picoline, Pyridine, 2-chloro-4-methyl-, MFCD00023418, 2-Chloro-4-Methyl Pyridine, 4-Picoline, 2-chloro-, 2-chloro-4-methyl-pyridine, 2-Chloro-4methylpyridine, 2-chlor-4-methylpyridine, 4-methyl-2-chloropyridine, 2-chlor-4-methyl pyridine, 2-Chloro-4-methylpyridine (2-Chloro-4-picoline), SCHEMBL111146, SCHEMBL423228, SCHEMBL452030, SCHEMBL789751, SCHEMBL790458, 2-Chloro-4-methylpyridine, 98%, BBL100687, SBB054263, STL554481, AKOS005145619, AC-3282, CS-W011139, HY-W010423, PB10051, PS-3670, SY004677, DB-027957, C1992, NS00030090, ST51037902, EN300-56134, F0001-1056, InChI=1/C6H6ClN/c1-5-2-3-8-6(7)4-5/h2-4H,1H

Application

2-Chloro-4-methylpyridine serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for antiviral and antihypertensive drugs. It is widely used in cross-coupling reactions (e.g., Suzuki, Stille) to create functionalized pyridine derivatives for medicinal chemistry. The compound also finds applications in agrochemical research as a precursor for herbicides and insecticides. Its reactivity with organometallic reagents enables the development of novel ligands for catalysis.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.