Description

2,5-Difluoroaniline (CAS No. 367-30-6) is a fluorinated aromatic amine with the molecular formula C₆H₅F₂N. This high-purity compound is a valuable building block in organic synthesis, particularly in the pharmaceutical and agrochemical industries. Its IUPAC name is 2,5-difluoroaniline, and it is characterized by the presence of two fluorine atoms at the 2- and 5-positions of the aniline ring, which enhances its reactivity and utility in cross-coupling reactions, nucleophilic substitutions, and other transformations.

Our 2,5-Difluoroaniline is rigorously tested to ensure exceptional quality, with purity levels suitable for research and industrial applications. It is supplied in a stable, well-sealed container to prevent degradation and ensure long-term storage stability. This compound is ideal for use in the synthesis of advanced intermediates, active pharmaceutical ingredients (APIs), and specialty chemicals.

Synonyms: 2,5-Difluoroaniline, 367-30-6, Benzenamine, 2,5-difluoro-, 2,5-difluorobenzenamine, Aniline, 2,5-difluoro-.

Properties

• CAS Number: 367-30-6
• Complexity: 97.1
• IUPAC Name: 2,5-difluoroaniline
• InChI: InChI=1S/C6H5F2N/c7-4-1-2-5(8)6(9)3-4/h1-3H,9H2
• InChI Key: YNOOQIUSYGWMSS-UHFFFAOYSA-N
• Exact Mass: 129.03900549
• Molecular Formula: C6H5F2N
• Molecular Weight: 129.11
• SMILES: C1=CC(=C(C=C1F)N)F
• Topological: 26
• Monoisotopic Mass: 129.03900549
• Synonyms: 2,5-Difluoroaniline, 367-30-6, Benzenamine, 2,5-difluoro-, 2,5-difluorobenzenamine, Aniline, 2,5-difluoro-, AI3-52637, 2,5-difluoroaminobenzene, EINECS 206-690-1, DTXSID70190144, NSC 3259, DTXCID80112635, 206-690-1, inchi=1/c6h5f2n/c7-4-1-2-5(8)6(9)3-4/h1-3h,9h, ynooqiusygwmss-uhfffaoysa-n, 2,5-difluoro-aniline, 2.5-difluoroaniline, MFCD00007651, NSC-3259, Aniline,5-difluoro-, 2,5-difluorophenylamine, Benzenamine,5-difluoro-, 2,5-Difluoro-phenylamine, (2,5-difluorophenyl)amine, SCHEMBL112382, 4JNJ8ZZ368, SCHEMBL3034723, SCHEMBL6561427, 2,5-Difluoroaniline, 99.5%, NSC3259, SBB069847, STL282257, AKOS000119719, AC-3236, CCG-302503, CS-W019973, PS-9158, DB-023941, D1634, NS00041451, EN300-19958, F2190-0459, Z104476212

Application

2,5-Difluoroaniline is widely used as a key intermediate in the synthesis of pharmaceuticals, agrochemicals, and dyes. Its fluorinated aromatic structure makes it valuable for introducing fluorine atoms into more complex molecules, enhancing their biological activity and metabolic stability. This compound is particularly useful in the preparation of herbicides, antifungal agents, and other specialty chemicals. Researchers also utilize it in the development of novel materials and ligands for catalysis.

Safety and Hazards

GHS Hazard Statements

• H302 (95.7%): Harmful if swallowed [Warning Acute toxicity, oral]
• H311 (10.6%): Toxic in contact with skin [Danger Acute toxicity, dermal]
• H312 (87.2%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (14.9%): Causes skin irritation [Warning Skin corrosion/irritation]
• H317 (85.1%): May cause an allergic skin reaction [Warning Sensitization, Skin]
• H319 (14.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H331 (10.6%): Toxic if inhaled [Danger Acute toxicity, inhalation]
• H332 (87.2%): Harmful if inhaled [Warning Acute toxicity, inhalation]

Precautionary Statements

• P261, P262, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P316, P317, P321, P330, P332+P317, P333+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (95.7%)
• Acute Tox. 3 (10.6%)
• Acute Tox. 4 (87.2%)
• Skin Irrit. 2 (14.9%)
• Skin Sens. 1 (85.1%)
• Eye Irrit. 2 (14.9%)
• Acute Tox. 3 (10.6%)
• Acute Tox. 4 (87.2%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.