Description

5-Fluoro-o-toluidine (CAS No. 367-29-3) is a high-purity fluorinated aromatic amine with the molecular formula C₇H₈FN and IUPAC name 5-fluoro-2-methylaniline. This specialized organic compound is a valuable building block in pharmaceutical, agrochemical, and materials science research. The presence of both fluorine and amine functional groups on the toluene backbone makes it a versatile intermediate for synthesizing more complex molecules. Our product is rigorously tested to ensure >98% purity (GC) and is supplied in sealed containers under inert atmosphere to prevent degradation. Typical impurities are monitored and kept below 0.5% each. Available in quantities from 1g to 1kg with custom packaging options. Store in cool, dry conditions away from light and oxidizing agents.

Properties

• CAS Number: 367-29-3
• Complexity: 94.9
• IUPAC Name: 5-fluoro-2-methyl-aniline
• InChI: InChI=1S/C7H8FN/c1-5-2-3-6(8)4-7(5)9/h2-4H,9H2,1H3
• InChI Key: JLCDTNNLXUMYFQ-UHFFFAOYSA-N
• Exact Mass: 125.064077422
• Molecular Formula: C7H8FN
• Molecular Weight: 125.14
• SMILES: CC1=C(C=C(C=C1)F)N
• Topological: 26
• Monoisotopic Mass: 125.064077422
• Synonyms: 5-Fluoro-o-toluidine, EINECS 206-689-6, DTXSID10190143, NSC 60730, DTXCID20112634, 206-689-6, 5-Fluoro-2-methylaniline, 367-29-3, 2-Amino-4-fluorotoluene, 3-fluoro-6-methylaniline, Benzenamine, 5-fluoro-2-methyl-, 5-Fluoro-2-methyl-phenylamine, MFCD00007764, 5-fluoro-2-methylphenylamine, NSC-60730, 5-Fluorotoluidine, NSC60730, VHR6M7NXK6, 5-fluoro-2-methyl aniline, 5-fluoro-2-methylbenzenamine, SCHEMBL291685, SCHEMBL655475, SCHEMBL3397377, (5-fluoro-2-methylphenyl)amine, JLCDTNNLXUMYFQ-UHFFFAOYSA-, 5-Fluoro-2-methylaniline, 99%, 5-FLUORO-2-METHYLANILINE (2-AMINO-4-FLUOROTOLUENE), AC-440, SBB004266, AKOS000119360, CCG-302497, CS-W013512, PS-9192, SB75390, BP-13150, DB-024316, A6326, F0232, NS00041712, 5-Fluoro-o-toluidine;2-Amino-4-fluorotoluene, EN300-20387, D70946, F0001-1052, Z104477984, InChI=1/C7H8FN/c1-5-2-3-6(8)4-7(5)9/h2-4H,9H2,1H3

Application

5-Fluoro-o-toluidine serves as a key intermediate in the synthesis of fluorinated pharmaceuticals, particularly in the development of novel antipsychotic and antibacterial agents. The compound is utilized in palladium-catalyzed cross-coupling reactions to create biaryl structures common in drug discovery. Researchers also employ it as a precursor for fluorescent dyes and advanced materials with unique electronic properties. In agrochemical research, it’s used to develop new pesticides with improved environmental profiles.

Safety and Hazards

GHS Hazard Statements

• H302 (98%): Harmful if swallowed [Warning Acute toxicity, oral]
• H311 (10.2%): Toxic in contact with skin [Danger Acute toxicity, dermal]
• H312 (89.8%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (98%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (98%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (98%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (83.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H373 (16.3%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

Precautionary Statements

• P260, P261, P262, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (98%)
• Acute Tox. 3 (10.2%)
• Acute Tox. 4 (89.8%)
• Skin Irrit. 2 (98%)
• Eye Irrit. 2 (98%)
• Acute Tox. 4 (98%)
• STOT SE 3 (83.7%)
• STOT RE 2 (16.3%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.