Description

2,4-Difluorophenol (CAS No. 367-27-1) is a high-purity fluorinated phenolic compound with the molecular formula C₆H₄F₂O. This versatile aromatic intermediate is widely utilized in pharmaceutical, agrochemical, and material science research due to its unique reactivity and fluorine substitution pattern. The compound is supplied as a clear to pale-yellow liquid with a characteristic phenolic odor, and is rigorously tested to meet stringent quality standards including GC purity ≥98%. Proper storage recommendations include protection from light and moisture at 2-8°C under inert atmosphere. This product is particularly valuable for nucleophilic aromatic substitution reactions and as a building block for more complex fluorinated architectures. Available in quantities from grams to multi-kilogram scale with custom packaging options.

Properties

• CAS Number: 367-27-1
• Complexity: 97.1
• IUPAC Name: 2,4-difluorophenol
• InChI: InChI=1S/C6H4F2O/c7-4-1-2-6(9)5(8)3-4/h1-3,9H
• InChI Key: NVWVWEWVLBKPSM-UHFFFAOYSA-N
• Exact Mass: 130.02302107
• Molecular Formula: C6H4F2O
• Molecular Weight: 130.09
• SMILES: C1=CC(=C(C=C1F)F)O
• Topological: 20.2
• Monoisotopic Mass: 130.02302107
• Synonyms: 2,4-Difluorophenol, 367-27-1, Phenol, 2,4-difluoro-, EINECS 206-688-0, AI3-62833, NVWVWEWVLBKPSM-UHFFFAOYSA-, DTXSID50190142, DTXCID60112633, 206-688-0, inchi=1/c6h4f2o/c7-4-1-2-6(9)5(8)3-4/h1-3,9h, nvwvwewvlbkpsm-uhfffaoysa-n, MFCD00009715, 2.4-difluorophenol, 2,4difluorophenol, 2,4-diflurophenol, 2,4 difluorophenol, 2, 4 difluorophenol, 2,4 difluoro phenol, 2,4-di-fluorophenol, 2,4-difluoro phenol, 2,4-difluoro-phenol, 2,4-Difluorophenol, 99%, SCHEMBL185204, SCHEMBL237271, CHEMBL395171, SCHEMBL1638471, SCHEMBL1711000, SCHEMBL7215830, SR-1C11, SBB085754, AKOS005145612, AC-3783, CS-W013441, HY-W012725, PS-9151, SY024987, DB-023939, D1832, NS00041727, ST51038082, EN300-22688, F0001-1051, Z147646792

Application

2,4-Difluorophenol serves as a key intermediate in the synthesis of active pharmaceutical ingredients, particularly for fluorinated drug candidates. The compound finds application in crop protection chemical development where its difluoro substitution pattern enhances biological activity. Researchers utilize this phenol derivative in materials science for creating specialty polymers with enhanced properties. Its reactivity makes it valuable for constructing more complex fluorinated aromatic systems through various coupling reactions.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (89.6%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (87.5%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H332 (91.7%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (87.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P330, P332+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Acute Tox. 4 (100%)
• Skin Irrit. 2 (89.6%)
• Eye Dam. 1 (87.5%)
• Acute Tox. 4 (91.7%)
• STOT SE 3 (87.5%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.