Description

2,4-Difluoroaniline (CAS No. 367-25-9) is a high-purity fluorinated aromatic amine with the molecular formula C₆H₅F₂N. This compound is a versatile building block in organic synthesis, particularly in the pharmaceutical and agrochemical industries. Its structure features two fluorine atoms at the 2- and 4-positions of the aniline ring, enhancing its reactivity and enabling selective functionalization. Available in liquid form with a clear to pale yellow appearance, it is packaged under inert conditions to ensure stability. Ideal for researchers and scientists, our 2,4-Difluoroaniline is rigorously tested for purity (>98% by GC) and consistency, making it suitable for demanding applications such as cross-coupling reactions, heterocycle synthesis, and material science research. Handle with care in a well-ventilated environment, as it may cause skin and eye irritation.

Properties

• CAS Number: 367-25-9
• Complexity: 97.1
• IUPAC Name: 2,4-difluoroaniline
• InChI: InChI=1S/C6H5F2N/c7-4-1-2-6(9)5(8)3-4/h1-3H,9H2
• InChI Key: CEPCPXLLFXPZGW-UHFFFAOYSA-N
• Exact Mass: 129.03900549
• Molecular Formula: C6H5F2N
• Molecular Weight: 129.11
• SMILES: C1=CC(=C(C=C1F)F)N
• Topological: 26
• Monoisotopic Mass: 129.03900549
• Physical Description: 2,4-difluoroaniline is a dark reddish-purple liquid.
• Boiling Point: 338 °F at 753 mmHg
• Melting Point: 18.5 °F
• Flash Point: 145 °F
• Solubility: 10 to 50 mg/mL at 68.9 °F
• Density: 1.268 – Denser than water; will sink
• Synonyms: 2,4-DIFLUOROANILINE, 2,4-Difluorobenzenamine, Benzenamine, 2,4-difluoro-, 2,4-Difluroaniline, Aniline, 2,4-difluoro-, CCRIS 4621, EINECS 206-687-5, UNII-40P93L7KWD, NSC 10297, BRN 2802556, 40P93L7KWD, DTXSID6025064, AI3-52650, NSC-10297, DTXCID905064, DIFLUOROANILINE, 2,4-, CEPCPXLLFXPZGW-UHFFFAOYSA-, EC 206-687-5, 2,4-DIFLUOROANILINE [MI], 4-12-00-01112 (Beilstein Handbook Reference), 206-687-5, cepcpxllfxpzgw-uhfffaoysa-n, inchi=1/c6h5f2n/c7-4-1-2-6(9)5(8)3-4/h1-3h,9h2, 367-25-9, 2,4-Difluorophenylamine, MFCD00007648, 2.4-difluoroaniline, 2,?4-?difluoro-Benzenamine, 2,4-Difluoro Aniline, 2,4-Difluoro-phenylamine, 2,4difluoroaniline, Aniline,4-difluoro-, 2,4 -difluoroaniline, 2,4 difluoro aniline, 2,4-di-fluoroaniline, 2,4-difluoro-aniline, 2, 4-Difluoroaniline, Benzenamine,4-difluoro-, (2,4-difluorophenyl)amine, SCHEMBL11425, SCHEMBL82353, 2,4-Difluoroaniline, 99%, BIDD:GT0098, SCHEMBL161777, SCHEMBL1777496, CHEMBL1423658, SCHEMBL14809126, NSC10297, Tox21_200620, SBB028235, STL264190, AKOS000119718, CCG-302504, CS-W020027, PS-9155, SDCCGMLS-0066219.P001, NCGC00091684-01, NCGC00091684-02, NCGC00258174-01, AC-10532, CAS-367-25-9, DB-005860, D1508, NS00009496, ST51038555, EN300-19930, A25254, Q27258348, F2182-0028, Z104476120, 2,4-difluoro-anilin;Aniline, 2,4-difluoro-;Benzenamine, 2,4-difluoro-

Application

2,4-Difluoroaniline is widely used as a key intermediate in the synthesis of pharmaceuticals, including antifungal and antibacterial agents. It serves as a precursor in the production of herbicides and pesticides due to its ability to introduce fluorine motifs into agrochemical compounds. Researchers also utilize it in the development of advanced materials, such as liquid crystals and polymers, where fluorinated aromatic units enhance thermal and chemical stability.

Safety and Hazards

GHS Hazard Statements

• H302 (99.4%): Harmful if swallowed [Warning Acute toxicity, oral]
• H311+H331 (66.2%): Toxic in contact with skin or if inhaled. [Danger Acute toxicity, dermal; acute toxicity, inhalation]
• H311 (97.5%): Toxic in contact with skin [Danger Acute toxicity, dermal]
• H315 (71.3%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (70.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H331 (96.8%): Toxic if inhaled [Danger Acute toxicity, inhalation]
• H335 (66.2%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H400 (67.5%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
• H410 (68.2%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P261, P262, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P316, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P391, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (99.4%)
• Acute Tox. 3 (97.5%)
• Skin Irrit. 2 (71.3%)
• Eye Irrit. 2 (70.7%)
• Acute Tox. 3 (96.8%)
• STOT SE 3 (66.2%)
• Aquatic Acute 1 (67.5%)
• Aquatic Chronic 1 (68.2%)

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