Description

1,2,4-Trifluorobenzene (CAS No. 367-23-7) is a high-purity fluorinated aromatic compound with the molecular formula C₆H₃F₃. This colorless to pale-yellow liquid is characterized by its unique trifluorinated benzene structure, offering exceptional chemical stability and reactivity for advanced synthetic applications. With a boiling point of approximately 85-87°C and a density of 1.28 g/mL at 25°C, it serves as a versatile building block in pharmaceutical, agrochemical, and materials science research. Our product is rigorously tested to ensure ≥98% purity (GC) and is supplied in amber glass bottles under inert atmosphere to prevent degradation. Ideal for nucleophilic aromatic substitution reactions, cross-coupling protocols, and as a precursor for liquid crystal materials.

Properties

• CAS Number: 367-23-7
• Complexity: 94.3
• IUPAC Name: 1,2,4-trifluorobenzene
• InChI: InChI=1S/C6H3F3/c7-4-1-2-5(8)6(9)3-4/h1-3H
• InChI Key: PEBWOGPSYUIOBP-UHFFFAOYSA-N
• Exact Mass: 132.01868458
• Molecular Formula: C6H3F3
• Molecular Weight: 132.08
• SMILES: C1=CC(=C(C=C1F)F)F
• Monoisotopic Mass: 132.01868458
• Synonyms: 1,2,4-Trifluorobenzene, 367-23-7, Benzene, 1,2,4-trifluoro-, 1,3,4-Trifluorobenzene, UNII-QWW4HNQ0L1, QWW4HNQ0L1, 1,2,5-trifluorobenzene, EINECS 206-684-9, NSC-10263, DTXSID30190140, NSC 10263, DTXCID40112631, 206-684-9, pebwogpsyuiobp-uhfffaoysa-n, MFCD00000305, 1,2,5-Trifluorobenzene; 1,3,4-Trifluorobenzene; NSC 10263, NSC10263, 1,4-Trifluorobenzene, Benzene,2,4-trifluoro-, 1,2,4-Trifluorobenzene #, SCHEMBL75726, SCHEMBL146705, SCHEMBL149390, SCHEMBL180042, SCHEMBL1393422, SCHEMBL5166432, 1,4-Trifluorobenzene, misnomer, 1,2,4-Trifluorobenzene, 98%, SBB085803, AKOS005762924, AC-10545, PS-10254, DB-002362, NS00041711, T1033, EN300-88531, Q27287530

Application

1,2,4-Trifluorobenzene is widely employed as a key intermediate in the synthesis of fluorinated pharmaceuticals, particularly for COX-2 inhibitors and antifungal agents. Its electron-deficient aromatic ring makes it valuable for creating advanced materials like liquid crystals and OLED components. Researchers utilize this compound in palladium-catalyzed cross-coupling reactions to introduce trifluorinated phenyl groups into complex molecules.

Safety and Hazards

GHS Hazard Statements

• H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]
• H315 (95.8%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (97.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 2 (100%)
• Skin Irrit. 2 (95.8%)
• Eye Irrit. 2 (97.9%)
• STOT SE 3 (97.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.