Description

Bis(trimethylsilyl) phosphite (CAS No. 3663-52-3) is a highly specialized organosilicon compound with the molecular formula C₆H₁₈O₃PSi₂. This reagent is widely utilized in organic synthesis and material science due to its unique phosphite functionality and silyl-protecting group properties. It serves as a versatile intermediate for the preparation of phosphorus-containing compounds, offering exceptional reactivity in phosphorylation and silylation reactions. With its high purity and stability, this product is ideal for advanced research applications, including catalysis, polymer modification, and pharmaceutical synthesis. Packaged under inert conditions to ensure optimal shelf life, our Bis(trimethylsilyl) phosphite meets stringent quality standards for laboratory and industrial use.

Properties

• CAS Number: 3663-52-3
• Complexity: 125
• IUPAC Name: bis(trimethylsilyl) phosphite
• InChI: InChI=1S/C6H18O3PSi2/c1-11(2,3)8-10(7)9-12(4,5)6/h1-6H3/q-1
• InChI Key: LRMDYQQIIKCKLX-UHFFFAOYSA-N
• Exact Mass: 225.05320950
• Molecular Formula: C6H18O3PSi2-
• Molecular Weight: 225.35
• SMILES: C[Si](C)(C)OP([O-])O[Si](C)(C)C
• Topological: 41.5
• Monoisotopic Mass: 225.05320950
• Synonyms: Bis(trimethylsilyl) phosphite, 3663-52-3, 2,2,6,6-Tetramethyl-3,5-dioxa-4-phospha-2,6-disilaheptan-4-olate, bis(trimethylsilyl)phosphite, DTXSID90596088, LRMDYQQIIKCKLX-UHFFFAOYSA-N

Bis(trimethylsilyl) phosphite is primarily employed as a phosphorylating agent in organic synthesis, enabling the efficient introduction of phosphorus moieties into target molecules. It finds application in the preparation of phosphonates and phosphates, which are critical intermediates in agrochemical and pharmaceutical development. Additionally, this compound is used in polymer chemistry to modify resin properties and enhance flame retardancy. Its role as a silylating agent further extends its utility in protecting hydroxyl groups during complex multi-step syntheses.

Safety and Hazards

GHS Hazard Statements

• H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.