Description

2-Bromo-4-fluoropyridine (CAS No. 357927-50-5) is a high-purity halogenated pyridine derivative widely used in pharmaceutical and agrochemical research. With the molecular formula C₅H₃BrFN, this compound serves as a versatile building block for nucleophilic substitution reactions, cross-coupling reactions, and other synthetic transformations. Its bromo and fluoro substituents enable selective functionalization, making it valuable for constructing complex heterocyclic scaffolds. Ideal for medicinal chemistry, material science, and catalysis research, our 2-Bromo-4-fluoropyridine is rigorously tested to ensure ≥98% purity (GC) and is supplied in secure, light-resistant packaging to maintain stability. Available in quantities from grams to kilograms, it is suitable for both lab-scale and industrial applications.

Properties

• CAS Number: 357927-50-5
• Complexity: 78.8
• IUPAC Name: 2-bromo-4-fluoro-pyridine
• InChI: InChI=1S/C5H3BrFN/c6-5-3-4(7)1-2-8-5/h1-3H
• InChI Key: AIEATTRZKVGMBO-UHFFFAOYSA-N
• Exact Mass: 174.94329
• Molecular Formula: C5H3BrFN
• Molecular Weight: 175.99
• SMILES: C1=CN=C(C=C1F)Br
• Topological: 12.9
• Monoisotopic Mass: 174.94329
• Synonyms: 2-Bromo-4-fluoropyridine, 357927-50-5, DTXSID70619446, DTXCID70570200, 640-737-0, 2-Bromo-4-fluoro-pyridine, MFCD09260909, PYRIDINE, 2-BROMO-4-FLUORO-, SCHEMBL688866, SCHEMBL4922644, SCHEMBL4923576, 2-Bromo-4-fluoropyridine, 96%, AIEATTRZKVGMBO-UHFFFAOYSA-N, BCP26769, SBB089109, AKOS005064104, AB50032, AC-1906, CS-W003601, HY-W003601, PS-8595, SY028281, B4760, EN300-94213

Application

2-Bromo-4-fluoropyridine is a key intermediate in the synthesis of active pharmaceutical ingredients (APIs) and agrochemicals. It is commonly employed in Suzuki-Miyaura and Buchwald-Hartwig coupling reactions to introduce pyridine motifs into target molecules. Researchers also utilize it in the development of fluorinated analogs for drug discovery and PET tracer synthesis. Its reactivity makes it valuable for constructing ligands in catalysis and functional materials.

Safety and Hazards

GHS Hazard Statements

• H302 (97.7%): Harmful if swallowed [Warning Acute toxicity, oral]
• H318 (95.3%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

Precautionary Statements

• P264, P264+P265, P270, P280, P301+P317, P305+P354+P338, P317, P330, and P501

Hazard Classes and Categories

• Acute Tox. 4 (97.7%)
• Eye Dam. 1 (95.3%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.