Description

(2-Chloro-1,1,2-trifluoroethyl)diethylamine (CAS No. 357-83-5) is a highly specialized fluorinated amine compound with the molecular formula C₆H₁₁ClF₃N. This organofluorine chemical is characterized by its unique trifluoroethyl and chloro-substituted structure, making it a valuable intermediate in synthetic organic chemistry and pharmaceutical research. The IUPAC name for this compound is 2-chloro-N,N-diethyl-1,1,2-trifluoroethanamine, and it is supplied as a high-purity liquid suitable for laboratory use. Its reactive chloro and trifluoroethyl groups enable versatile applications in nucleophilic substitution reactions, fluorination processes, and as a building block for more complex molecules. Proper handling under inert conditions is recommended due to its potential sensitivity to moisture and air.

Properties

• CAS Number: 357-83-5
• Complexity: 116
• IUPAC Name: 2-chloro-N,N-diethyl-1,1,2-trifluoro-ethanamine
• InChI: InChI=1S/C6H11ClF3N/c1-3-11(4-2)6(9,10)5(7)8/h5H,3-4H2,1-2H3
• InChI Key: BDZHKUAKSMWSAJ-UHFFFAOYSA-N
• Exact Mass: 189.0532115
• Molecular Formula: C6H11ClF3N
• Molecular Weight: 189.60
• SMILES: CCN(CC)C(C(F)Cl)(F)F
• Topological: 3.2
• Monoisotopic Mass: 189.0532115
• Synonyms: 357-83-5, (2-Chloro-1,1,2-trifluoroethyl)diethylamine, 2-chloro-n,n-diethyl-1,1,2-trifluoroethanamine, N,N-Diethyl(2-chloro-1,1,2-trifluoroethyl)amine, n,n-diethyl-2-chloro-1,1,2-trifluoroethylamine, N-(2-Chloro-1,1,2-trifluoroethyl)diethylamine, SCHEMBL966410, DTXSID00276369, DTXSID20957103, MFCD00054672, SBB091007, AKOS007930480, 2-chloro-1,1,2-trifluorotriethylamine, 114440-20-9, 1,1,2-trifluoro-2-chloroethyldiethylamine, ST51040170, 1-diethylamino-1,1,2trifluoro-2-chloroethane, 1-diethylamino-1,1,2-trifluoro-2-chloroethane, 2-chloro-1-diethylamino-1,1,2-trifluoroethane, diethyl (2-chloro-1,1,2-trifluoroethyl)amine, 2-chloro-n,n-diethyl-1,1,2-trifluoroethylamine, n-(2-chloro-1,1,2-trifluoroethyl) diethylamine, N-(2-chloro-1,1,2-trifluoroethyl)-diethylamine, (2-Chloro-1,1,2-trifluoroethyl)-N,N-diethylamine, (2-Chloro-1,1,2-trifluoroethyl)diethylamine, 97%, 2-Chloro-N,N-diethyl-1,1,2-trifluoroethan-1-amine

Application

This compound serves as a key intermediate in the synthesis of fluorinated pharmaceuticals and agrochemicals. Researchers utilize it in nucleophilic substitution reactions to introduce trifluoroethylamine moieties into target molecules. Its reactivity also makes it suitable for developing novel fluorinated ligands and catalysts in asymmetric synthesis. Additionally, it finds use in material science for modifying surface properties of polymers.

Safety and Hazards

GHS Hazard Statements

• H226 (88.6%): Flammable liquid and vapor [Warning Flammable liquids]
• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P260, P264, P280, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P321, P363, P370+P378, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (88.6%)
• Skin Corr. 1B (100%)

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