Description

Pentafluoropropionic Anhydride (CAS No. 356-42-3) is a high-purity fluorinated organic compound with the molecular formula C₆F₁₀O₃. This anhydride is derived from pentafluoropropionic acid and is widely used as a versatile reagent in organic synthesis, particularly in the introduction of pentafluoropropionyl groups. Its IUPAC name is 2,2,3,3,3-pentafluoropropanoyl 2,2,3,3,3-pentafluoropropanoate. With excellent reactivity and stability, it is ideal for acylation reactions, peptide modifications, and derivatization in analytical chemistry. Packaged under inert conditions to ensure maximum shelf life and performance, this product meets the stringent requirements of research and industrial applications.

Properties

• CAS Number: 356-42-3
• Complexity: 342
• IUPAC Name: 2,2,3,3,3-pentafluoropropanoyl 2,2,3,3,3-pentafluoropropanoate
• InChI: InChI=1S/C6F10O3/c7-3(8,5(11,12)13)1(17)19-2(18)4(9,10)6(14,15)16
• InChI Key: XETRHNFRKCNWAJ-UHFFFAOYSA-N
• Exact Mass: 309.96877548
• Molecular Formula: C6F10O3
• Molecular Weight: 310.05
• SMILES: C(=O)(C(C(F)(F)F)(F)F)OC(=O)C(C(F)(F)F)(F)F
• Topological: 43.4
• Monoisotopic Mass: 309.96877548
• Physical Description: Colorless liquid;
• Synonyms: Pentafluoropropionic anhydride, Perfluoropropionic anhydride, pentafluoropropanoic anhydride, Pentafluoropropionic acid anhydride, Propanoic acid, pentafluoro-, anhydride, Perfluoropropionic acid anhydride, 2,2,3,3,3-pentafluoropropanoyl 2,2,3,3,3-pentafluoropropanoate, Propionic acid, pentafluoro-, anhydride, UNII-0LFE7U11O5, 0LFE7U11O5, 2,2,3,3,3-pentafluoropropanoic anhydride, EINECS 206-604-2, Perfluoropropanoic anhydride, NSC 174167, NSC-174167, DTXSID70870515, PENTAFLUOROPROPIONYL ANHYDRIDE, Propanoic acid, 2,2,3,3,3-pentafluoro-, 1,1′-anhydride, 2,2,3,3,3-pentafluoropropionic anhydride, 2,2,3,3,3-Pentafluoropropionic acid anhydride, PFPAH, DTXCID90818232, Propionic acid, pentafluoro, anhydride, 206-604-2, un3265, xetrhnfrkcnwaj-uhfffaoysa-n, 356-42-3, C6F10O3, MFCD00000429, Decafluoropropionic Anhydride, Propionic acid, anhydride, perfluoro-propionic anhydride, SCHEMBL153663, CS-B0895, Pentafluoropropionic anhydride, 99%, NSC174167, AKOS005063449, FP32316, FS-4784, NS00019370, P0566, 1,1,2,2,2-Pentafluoropropanoic anhydride #, EN300-305496, F14888, pentafluoropropanoyl 2,2,3,3,3-pentafluoropropanoate, Pentafluoropropionic anhydride, purum, >=97.0% (GC), Q27236944, F0001-1027, Pentafluoropropionic anhydride, for GC derivatization, 99%, 1,1,2,2,2-Pentafluoropropanoic anhydride;2,2,3,3,3-Pentafluoropropionic acid anhydride

Application

Pentafluoropropionic anhydride is commonly employed as a derivatizing agent in gas chromatography (GC) and mass spectrometry (MS) for enhancing the volatility and detectability of analytes. It is also used in the synthesis of fluorinated pharmaceuticals and agrochemicals due to its ability to introduce pentafluoropropionyl groups. Additionally, this reagent finds applications in peptide chemistry for N-terminal modification and in material science for surface functionalization.

Safety and Hazards

GHS Hazard Statements

• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H332 (18.2%): Harmful if inhaled [Warning Acute toxicity, inhalation]

Precautionary Statements

• P260, P261, P264, P271, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P363, P405, and P501

Hazard Classes and Categories

• Skin Corr. 1B (100%)
• Acute Tox. 4 (18.2%)

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