Description

3,5-Dibromo-2-pyridylamine (CAS No. 35486-42-1) is a high-purity brominated pyridine derivative with the molecular formula C₅H₄Br₂N₂. This compound, also known by its IUPAC name 3,5-dibromopyridin-2-amine, is a versatile building block in organic synthesis and pharmaceutical research. It features two bromine atoms at the 3- and 5-positions of the pyridine ring, enhancing its reactivity for cross-coupling reactions such as Suzuki or Buchwald-Hartwig amination. With a molecular weight of 251.91 g/mol, this off-white to light brown crystalline powder is ideal for researchers developing novel heterocyclic compounds, agrochemicals, or medicinal chemistry intermediates. Our product is rigorously tested for purity (typically ≥95% by HPLC) and is packaged under inert conditions to ensure stability. Available in quantities from grams to kilograms, it is suitable for lab-scale experiments or industrial-scale applications.

Properties

• CAS Number: 35486-42-1
• Complexity: 99
• IUPAC Name: 3,5-dibromopyridin-2-amine
• InChI: InChI=1S/C5H4Br2N2/c6-3-1-4(7)5(8)9-2-3/h1-2H,(H2,8,9)
• InChI Key: WJMJWMSWJSACSN-UHFFFAOYSA-N
• Exact Mass: 251.87207
• Molecular Formula: C5H4Br2N2
• Molecular Weight: 251.91
• SMILES: C1=C(C=NC(=C1Br)N)Br
• Topological: 38.9
• Monoisotopic Mass: 249.87412
• Synonyms: 3,5-Dibromo-2-pyridylamine, EINECS 252-590-6, DTXSID20188990, NSC 170846, DTXCID80111481, 252-590-6, 2-Amino-3,5-dibromopyridine, 35486-42-1, 3,5-dibromopyridin-2-amine, 2-Pyridinamine, 3,5-dibromo-, MFCD00038041, 3,5-Dibromo-2-pyridinamine, 3,5-dibromo-2-pyridinylamine, NSC170846, Maybridge1_001693, 3,5-dibromopyridine-2-amine, MLS000702186, 3,5-Dibromo-2-aminopyridine, SCHEMBL971307, 2-amino-3,5-dibromo pyridine, SCHEMBL4056781, CHEMBL1603203, SCHEMBL10824539, HMS546E21, WJMJWMSWJSACSN-UHFFFAOYSA-, HMS2517B09, HMS3376F17, Pyridine, 2-amino-3,5-dibromo-, BBL000187, CL0249, SBB000910, STK135408, 2-Amino-3,5-dibromopyridine, 97%, AKOS000267430, AB01699, AC-5425, CCG-235521, CS-W002171, NSC-170846, NCGC00247075-01, AS-14951, SMR000224601, SY005185, A1588, A1734, NS00029866, ST50186523, EN300-114818, AC-907/30003001, BRD-K08360730-001-08-5, InChI=1/C5H4Br2N2/c6-3-1-4(7)5(8)9-2-3/h1-2H,(H2,8,9)

Application

3,5-Dibromo-2-pyridylamine serves as a key intermediate in the synthesis of pharmaceuticals, particularly in the development of kinase inhibitors and antiviral agents. Its bromine substituents make it valuable for palladium-catalyzed coupling reactions to construct complex nitrogen-containing heterocycles. Researchers also utilize this compound in material science for creating functionalized pyridine-based ligands in coordination chemistry. In agrochemical research, it acts as a precursor for crop protection agents due to its bioactive pyridine core.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.9%)

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