Description

Acetamide, 2-chloro-2,2-difluoro- (CAS: 354-28-9) is a highly specialized fluorinated organic compound with the molecular formula C₂H₂ClF₂NO. This chemical is widely recognized in research and industrial applications due to its unique structural properties, combining chloro and difluoro substituents on an acetamide backbone. It is available in high-purity grades suitable for advanced synthetic chemistry, pharmaceutical intermediates, and material science research. The compound is characterized by its stability under controlled conditions and its reactivity in nucleophilic substitution reactions, making it a valuable building block for complex molecular architectures. Proper handling, including the use of personal protective equipment (PPE) and adherence to safety protocols, is essential due to its potential hazards.

Properties

• CAS Number: 354-28-9
• Complexity: 93.7
• IUPAC Name: 2-chloro-2,2-difluoro-acetamide
• InChI: InChI=1S/C2H2ClF2NO/c3-2(4,5)1(6)7/h(H2,6,7)
• InChI Key: PSAKKOKLSDIKEK-UHFFFAOYSA-N
• Exact Mass: 128.9792977
• Molecular Formula: C2H2ClF2NO
• Molecular Weight: 129.49
• SMILES: C(=O)(C(F)(F)Cl)N
• Topological: 43.1
• Monoisotopic Mass: 128.9792977
• Synonyms: Chlorodifluoroacetamide, 354-28-9, Acetamide, 2-chloro-2,2-difluoro-, Difluorochloroacetamide, NSC 9448, EINECS 206-555-7, AI3-52633, DTXSID1059866, DTXCID6039009, psakkoklsdikek-uhfffaoysa-n, 2-Chloro-2,2-difluoroacetamide, NSC9448, MFCD00039775, Acetamide,2-difluoro-, SCHEMBL751015, SCHEMBL2231413, 2-Chloro-2,2-difluoro-acetamid, 2-Chloro-2,2-difluoroacetamide #, ALBB-025910, NSC-9448, SBB017538, AKOS006223213, 2-chloranyl-2,2-bis(fluoranyl)ethanamide, LS-08726, DB-048807, NS00041655, ST45021349, H35296, A822794

Acetamide, 2-chloro-2,2-difluoro- is primarily used as a versatile intermediate in organic synthesis, particularly in the preparation of fluorinated pharmaceuticals and agrochemicals. Its reactive chloro and difluoro groups enable selective modifications, making it valuable for constructing bioactive molecules. Researchers also employ this compound in material science to develop novel polymers with enhanced thermal and chemical resistance. Additionally, it serves as a precursor in the synthesis of specialty chemicals for electronic and coating applications.

Safety and Hazards

GHS Hazard Statements

• H302 (90.5%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (90.5%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (90.5%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (90.5%)
• Acute Tox. 4 (90.5%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (90.5%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.