Description

1-Benzyl-1H-pyrazol-5-amine (CAS No. 3528-51-6) is a high-purity organic compound with the molecular formula C₁₀H₁₁N₃ and IUPAC name 2-benzylpyrazol-3-amine. This heterocyclic amine features a pyrazole core substituted with a benzyl group at the 1-position and an amine group at the 5-position, making it a valuable intermediate in pharmaceutical and agrochemical research. Our product is rigorously tested to ensure ≥95% purity (HPLC) and is supplied as a crystalline solid with excellent batch-to-batch consistency. Ideal for medicinal chemistry applications, this compound is particularly useful in the development of kinase inhibitors and other bioactive molecules. The product is packaged under inert atmosphere to ensure stability and shipped with comprehensive analytical data (including ¹H NMR, HPLC, and MS spectra).

Properties

• CAS Number: 3528-51-6
• Complexity: 154
• IUPAC Name: 2-benzylpyrazol-3-amine
• InChI: InChI=1S/C10H11N3/c11-10-6-7-12-13(10)8-9-4-2-1-3-5-9/h1-7H,8,11H2
• InChI Key: CJDYNUBRSBSSJU-UHFFFAOYSA-N
• Exact Mass: 173.095297364
• Molecular Formula: C10H11N3
• Molecular Weight: 173.21
• SMILES: C1=CC=C(C=C1)CN2C(=CC=N2)N
• Topological: 43.8
• Monoisotopic Mass: 173.095297364
• Synonyms: 1-Benzyl-1H-pyrazol-5-amine, 3528-51-6, 1-(PHENYLMETHYL)-1H-PYRAZOL-5-AMINE, EINECS 222-550-2, DTXSID30188764, DTXCID90111255, 222-550-2, 2-benzylpyrazol-3-amine, 1H-Pyrazol-5-amine, 1-(phenylmethyl)-, MFCD03596769, 1-benzylpyrazole-5-ylamine, 5-Amino-1-benzylpyrazole, JL5SY6Q8TW, SCHEMBL568868, 1–benzyl–5–aminopyrazole, 5-amino-1-phenylmethylpyrazole, Pyrazole, 5-amino-1-benzyl-, 2-Benzyl-2H-pyrazol-3-ylamine, (1-Benzyl-1H-pyrazol-5-yl)amine, BBL030018, SBB076420, STK940321, AKOS000118456, BAS 07322152, BS-13724, SY101567, DB-069190, CS-0060524, NS00029820, ST45234216, EN300-11678, W17059, Z57980554

Application

1-Benzyl-1H-pyrazol-5-amine serves as a key building block in medicinal chemistry, particularly for the synthesis of kinase inhibitors and other heterocyclic bioactive compounds. Researchers utilize this amine-functionalized pyrazole derivative in palladium-catalyzed cross-coupling reactions to create diverse pharmacophores. The benzyl substitution pattern makes it valuable for developing compounds with improved blood-brain barrier permeability in CNS drug discovery programs.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (100%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.