Description

1-Chloro-4-fluorobenzene (CAS No. 352-33-0) is a high-purity aromatic compound with the molecular formula C₆H₄ClF. This halogenated benzene derivative is a colorless to pale-yellow liquid with a characteristic aromatic odor, widely utilized in organic synthesis and pharmaceutical research. Its unique structure, featuring both chloro and fluoro substituents in the para position, makes it a versatile intermediate for cross-coupling reactions, nucleophilic substitutions, and as a building block for advanced materials. Our product is rigorously tested to ensure ≥98% purity (GC), with low levels of impurities, making it ideal for sensitive applications. Packaged under inert gas to maintain stability, it is available in quantities ranging from grams to multi-kilogram scales to meet both laboratory and industrial demands.

Properties

• CAS Number: 352-33-0
• Complexity: 66.9
• IUPAC Name: 1-chloro-4-fluoro-benzene
• InChI: InChI=1S/C6H4ClF/c7-5-1-3-6(8)4-2-5/h1-4H
• InChI Key: RJCGZNCCVKIBHO-UHFFFAOYSA-N
• Exact Mass: 129.9985560
• Molecular Formula: C6H4ClF
• Molecular Weight: 130.55
• SMILES: C1=CC(=CC=C1F)Cl
• Monoisotopic Mass: 129.9985560
• Physical Description: Colorless liquid;
• Vapor Pressure: 8.19 [mmHg]
• Synonyms: 1-Chloro-4-fluorobenzene, 352-33-0, p-Chlorofluorobenzene, p-Fluorochlorobenzene, Benzene, 1-chloro-4-fluoro-, 1-Fluoro-4-chlorobenzene, EINECS 206-521-1, NSC 10272, DTXSID2059853, pChlorofluorobenzene, pFluorochlorobenzene, 1Fluoro4chlorobenzene, Benzene, 1chloro4fluoro, DTXCID1038959, 206-521-1, inchi=1/c6h4clf/c7-5-1-3-6(8)4-2-5/h1-4, 4-Chlorofluorobenzene, 4-Fluorochlorobenzene, 1-Chloro-4-fluoro-benzene, 55256-17-2, 1,4-Fluorochlorobenzene, 1-Chloro-4-fluorobenzene, 98%, NSC-10272, NSC10272, p-chloro-fluorobenzene, 4-fluorophenyl chloride, 1-chloro-4-fluorbenzene, 1-Chlor-4-fluor-benzol, 4MH2SJ5JJR, SCHEMBL35226, SCHEMBL69724, SCHEMBL75548, SCHEMBL5581408, SCHEMBL5581454, SCHEMBL5776485, 1-chloranyl-4-fluoranyl-benzene, SCHEMBL15052001, MFCD00000603, SBB085775, AKOS006222741, AC-10630, PS-11967, A6188, NS00041648, ST50409630, EN300-97493, D89284, A822665

Application

1-Chloro-4-fluorobenzene is a key intermediate in the synthesis of pharmaceuticals, agrochemicals, and liquid crystals. It serves as a precursor for Suzuki-Miyaura and Buchwald-Hartwig coupling reactions to create biaryl structures. In material science, it is used to modify polymers and dyes for enhanced thermal and chemical resistance. Its para-substituted reactivity also makes it valuable in the development of fluorinated aromatic compounds for electronic applications.

Safety and Hazards

GHS Hazard Statements

• H226 (94.1%): Flammable liquid and vapor [Warning Flammable liquids]
• H315 (90.2%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (90.2%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (17.6%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (90.2%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P317, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (94.1%)
• Skin Irrit. 2 (90.2%)
• Eye Irrit. 2 (90.2%)
• Acute Tox. 4 (17.6%)
• STOT SE 3 (90.2%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.