Description

p-Fluorotoluene (CAS No. 352-32-9) is a high-purity fluorinated aromatic compound with the molecular formula C₇H₇F and IUPAC name 1-fluoro-4-methylbenzene. This colorless to pale yellow liquid is widely used in organic synthesis, pharmaceutical intermediates, and agrochemical research due to its stable aromatic ring structure and reactive fluorine substituent. With a boiling point of approximately 115-117°C and a density of 1.00 g/mL at 25°C, p-Fluorotoluene is soluble in common organic solvents like ethanol, ether, and acetone but insoluble in water. Our product is rigorously tested for purity (typically ≥98% by GC) and is supplied in secure, chemically resistant packaging to ensure stability and shelf life. Ideal for nucleophilic substitution reactions, cross-coupling reactions, and as a building block for advanced materials.

Properties

• CAS Number: 352-32-9
• Complexity: 62.8
• IUPAC Name: 1-fluoro-4-methyl-benzene
• InChI: InChI=1S/C7H7F/c1-6-2-4-7(8)5-3-6/h2-5H,1H3
• InChI Key: WRWPPGUCZBJXKX-UHFFFAOYSA-N
• Exact Mass: 110.053178385
• Molecular Formula: C7H7F
• Molecular Weight: 110.13
• SMILES: CC1=CC=C(C=C1)F
• Monoisotopic Mass: 110.053178385
• Physical Description: 4-fluorotoluene appears as a colorless liquid with an aromatic odor. May float or sink in water.
• Boiling Point: 241.9 °F at 760 mmHg
• Melting Point: -70.2 °F
• Flash Point: 105 °F
• Density: 1.0007 at 68 °F – Denser than water; will sink
• Vapor Pressure: 39.81 mmHg
• Synonyms: 4-Fluorotoluene, P-FLUOROTOLUENE, 352-32-9, 1-Fluoro-4-methylbenzene, Benzene, 1-fluoro-4-methyl-, p-Fluoromethylbenzene, Toluene, p-fluoro-, 1-Methyl-4-fluorobenzene, p-Fluoromethyl benzene, p-tolyl fluoride, NSC 8861, NUD6WZ1B8F, EINECS 206-520-6, BRN 1362373, AI3-28561, NSC-8861, FLUOROTOLUENE, P-, P-FLUOROTOLUENE [MI], DTXSID7059852, 4-05-00-00800 (Beilstein Handbook Reference), UN-2388, DTXCID6038958, 4-FLUORO-1-METHYLBENZENE, 206-520-6, inchi=1/c7h7f/c1-6-2-4-7(8)5-3-6/h2-5h,1h, para-Fluorotoluene, 1-Fluoro-4-methyl-benzene, UN2388, CHEMBL346605, 2194-09-4, UNII-NUD6WZ1B8F, MFCD00000358, 4-Fluorobenzyl radical, 4-Fluorotoluene-?-d1, 4-Fluorotoluene, 97%, WLN: FR D, SCHEMBL12689, SCHEMBL27051, SCHEMBL27709, SCHEMBL98841, SCHEMBL146776, (4-Fluorophenyl)methyl radical, SCHEMBL1804958, SCHEMBL7257251, NSC8861, GFA08890, BDBM50008544, STL280319, AKOS009031486, BP-12816, BS-23827, DB-023922, F0041, NS00041670, EN300-19368, p-Fluorotoluene [UN2388] [Flammable liquid], Q26840772, F0001-1019, Z104473648

Application

p-Fluorotoluene is primarily employed as a versatile intermediate in pharmaceutical and agrochemical synthesis, where its fluorine moiety enhances bioavailability and metabolic stability. It serves as a key precursor in the production of fluorinated liquid crystals for display technologies and specialty polymers. Researchers also utilize it in Suzuki-Miyaura and other palladium-catalyzed cross-coupling reactions to construct complex aromatic systems.

Safety and Hazards

GHS Hazard Statements

• H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]
• H302 (20.9%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (20.9%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (77.5%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (77.5%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (40.6%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (58.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 2 (100%)
• Acute Tox. 4 (20.9%)
• Acute Tox. 4 (20.9%)
• Skin Irrit. 2 (77.5%)
• Eye Irrit. 2A (77.5%)
• Acute Tox. 4 (40.6%)
• STOT SE 3 (58.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.