Description

N-[3-(Trifluoromethyl)phenyl]acetamide (CAS No. 351-36-0) is a high-purity organic compound with the molecular formula C₉H₈F₃NO. This trifluoromethyl-substituted acetamide derivative is a valuable building block in pharmaceutical and agrochemical research. The presence of the electron-withdrawing trifluoromethyl group enhances its reactivity, making it particularly useful in nucleophilic substitution reactions. Available in quantities from milligrams to kilograms, our product is rigorously tested to ensure ≥98% purity by HPLC and is supplied as a white to off-white crystalline powder. Suitable for use in medicinal chemistry, material science, and as a precursor for further functionalization. Each batch is accompanied by comprehensive analytical data including ¹H NMR, ¹³C NMR, and mass spectrometry reports. Store in a cool, dry place at 2-8°C under inert atmosphere for optimal stability.

Properties

• CAS Number: 351-36-0
• Complexity: 215
• IUPAC Name: N-[3-(trifluoromethyl)phenyl]acetamide
• InChI: InChI=1S/C9H8F3NO/c1-6(14)13-8-4-2-3-7(5-8)9(10,11)12/h2-5H,1H3,(H,13,14)
• InChI Key: HNIPNANLYHXYDE-UHFFFAOYSA-N
• Exact Mass: 203.05579836
• Molecular Formula: C9H8F3NO
• Molecular Weight: 203.16
• SMILES: CC(=O)NC1=CC=CC(=C1)C(F)(F)F
• Topological: 29.1
• Monoisotopic Mass: 203.05579836
• Synonyms: N-(3-(Trifluoromethyl)phenyl)acetamide, m-Trifluoromethylacetanilide, N-[3-(Trifluoromethyl)phenyl]acetamide, 3-Trifluoromethylacetanilide, USAF MA-14, 3′-Trifluoromethylacetanilide, m-Trifluoromethyl acetanilide, Acetanilide, 3-(trifluoromethyl)-, alpha,alpha,alpha-Trifluoro-m-acetotoluidide, Acetamide, N-[3-(trifluoromethyl)phenyl]-, NSC 30581, EINECS 206-512-2, BRN 2213222, N-(alpha,alpha,alpha-Trifluoro-m-tolyl)acetamide, AI3-13006, Acetamide, N-(3-(trifluoromethyl)phenyl)-, m-Acetotoluidide, alpha,alpha,alpha-trifluoro-, DTXSID60188595, 3-12-00-01989 (Beilstein Handbook Reference), DTXCID20111086, Acetamide, N-3-(trifluoromethyl)phenyl-, Acetamide, N-(3-(trifluoromethyl)phenyl)-(9CI), 206-512-2, 351-36-0, 3-(TRIFLUOROMETHYL)ACETANILIDE, 3-Acetamidobenzotrifluoride, 3′-(trifluoromethyl)acetanilide, 1-Acetamido-3-trifluoromethylbenzene, m-(Trifluoromethyl)acetanilide, Acetamide, N-(3-(trifluoromethyl)phenyl)- (9CI), NSC-30581, NSC-60257, WLN: FXFFR CMV1, m-Acetaminobenzotrifluoride, m-Acetotoluidide, .alpha.,.alpha.,.alpha.-trifluoro-, .alpha.,.alpha.-Trifluoro-m-acetotoluidide, m-Acetotoluidide,.alpha.,.alpha.-trifluoro-, N-(.alpha.,.alpha.-Trifluoro-m-tolyl)acetamide, NSC60257, MFCD00000383, Maybridge1_005905, N-(3-TRIFLUOROMETHYLPHENYL)ACETAMIDE, EU7ETU84SK, SCHEMBL505220, SCHEMBL2083939, SCHEMBL2894937, SCHEMBL5454303, SCHEMBL5782488, CHEMBL4070027, HMS558E09, BSYSFLHKSDXURE-UHFFFAOYSA-N, NSC30581, SBB008117, N-Acetyl-3-Trifluoromethylbenzenamine, AKOS003626056, FS-3859, N-(3-Trifluoromethyl-phenyl)-acetamide, SB77829, ST074032, N-[3-(Trifluoromethyl)phenyl]acetamide #, DB-048735, CS-0187542, NS00042103, N-Acetyl-alpha,alpha,alpha-trifluoro-m-toluidine, AE-641/02012023, SR-01000397478, .alpha.,.alpha.,.alpha.-Trifluoro-m-acetotoluidide, SR-01000397478-1, N-(.alpha.,.alpha.,.alpha.-Trifluoro-m-tolyl)acetamide

Application

N-[3-(Trifluoromethyl)phenyl]acetamide serves as a key intermediate in the synthesis of pharmaceutical compounds, particularly those targeting central nervous system disorders. The trifluoromethyl group enhances metabolic stability, making it valuable in drug discovery programs. This compound is also utilized in material science for developing specialty polymers with unique electronic properties. Researchers employ it as a precursor for synthesizing more complex fluorinated organic molecules.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (98.6%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (98.6%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (98.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Skin Irrit. 2 (98.6%)
• Eye Irrit. 2 (98.6%)
• STOT SE 3 (98.6%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.