Description

4′-Bromo-3′-fluoroacetanilide (CAS No. 351-30-4) is a high-purity bromo- and fluoro-substituted acetanilide derivative with the molecular formula C₈H₇BrFNO. This compound, also known as N-(4-bromo-3-fluorophenyl)acetamide, is a valuable intermediate in organic synthesis and pharmaceutical research. Its unique structure, featuring both bromo and fluoro substituents on the aromatic ring, makes it a versatile building block for the development of novel bioactive molecules, agrochemicals, and materials. Our product is rigorously tested to ensure ≥98% purity (HPLC) and is supplied as a white to off-white crystalline powder. Suitable for use in cross-coupling reactions, medicinal chemistry, and as a precursor for further functionalization. Packaged under inert gas to ensure stability and longevity.

Properties

• CAS Number: 351-30-4
• Complexity: 176
• IUPAC Name: N-(4-bromo-3-fluoro-phenyl)acetamide
• InChI: InChI=1S/C8H7BrFNO/c1-5(12)11-6-2-3-7(9)8(10)4-6/h2-4H,1H3,(H,11,12)
• InChI Key: GAQUWJRFYLETKX-UHFFFAOYSA-N
• Exact Mass: 230.96950
• Molecular Formula: C8H7BrFNO
• Molecular Weight: 232.05
• SMILES: CC(=O)NC1=CC(=C(C=C1)Br)F
• Topological: 29.1
• Monoisotopic Mass: 230.96950
• Synonyms: 351-30-4, 4′-Bromo-3′-fluoroacetanilide, N-(4-bromo-3-fluorophenyl)acetamide, DTXSID90378366, DTXCID90329393, 609-068-1, 4-bromo-3-fluoroacetanilide, 4-bromo-3′-fluoroacetanilide, Acetamide, N-(4-bromo-3-fluorophenyl)-, MFCD00672937, SCHEMBL9335, GAQUWJRFYLETKX-UHFFFAOYSA-N, 4”-Bromo-3”-fluoroacetanilide, SBB097859, AKOS009158316, N-(4-bromo-3-fluoro-phenyl)acetamide, PS-7697, DB-403319, CS-0194763, 4 inverted exclamation marka-Bromo-3 inverted exclamation marka-fluoroacetanilide

Application

4′-Bromo-3′-fluoroacetanilide is widely utilized as a key intermediate in pharmaceutical research, particularly in the synthesis of fluorinated drug candidates. Its bromo and fluoro substituents enable participation in palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura and Buchwald-Hartwig couplings. Researchers also employ this compound in the development of agrochemicals and specialty materials due to its robust aromatic framework. Its acetamide moiety serves as a protective group or functional handle for further derivatization.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.