Description

4-Fluorobenzenesulfonyl chloride (CAS No. 349-88-2) is a high-purity organosulfur compound with the molecular formula C₆H₄ClFO₂S. This reactive intermediate is widely utilized in organic synthesis, particularly in the preparation of sulfonamides and sulfonate esters. The compound features a fluorinated aromatic ring coupled with a highly electrophilic sulfonyl chloride group, making it an essential reagent for introducing the 4-fluorobenzenesulfonyl moiety into target molecules. It is supplied as a clear to pale yellow liquid (or crystalline solid, depending on storage conditions) with a characteristic pungent odor. Suitable for use under inert conditions, this chemical is rigorously tested for purity (typically ≥97% by GC or HPLC) and is packaged in amber glass bottles to ensure stability. Ideal for pharmaceutical, agrochemical, and materials science research.

Properties

• CAS Number: 349-88-2
• Complexity: 213
• IUPAC Name: 4-fluorobenzenesulfonyl chloride
• InChI: InChI=1S/C6H4ClFO2S/c7-11(9,10)6-3-1-5(8)2-4-6/h1-4H
• InChI Key: BFXHJFKKRGVUMU-UHFFFAOYSA-N
• Exact Mass: 193.9604564
• Molecular Formula: C6H4ClFO2S
• Molecular Weight: 194.61
• SMILES: C1=CC(=CC=C1F)S(=O)(=O)Cl
• Topological: 42.5
• Monoisotopic Mass: 193.9604564
• Physical Description: Melting point = 30 deg C; White solid; mp = 35-38 deg C;
• Synonyms: 4-Fluorobenzenesulfonyl chloride, 349-88-2, p-Fluorobenzenesulfonyl chloride, Benzenesulfonyl chloride, 4-fluoro-, 4-Fluorophenylsulfonyl chloride, Benzenesulfonyl chloride, p-fluoro-, EINECS 206-493-0, NSC 140128, DTXSID3059846, BFXHJFKKRGVUMU-UHFFFAOYSA-, 4fluorophenylsulfonyl chloride, pFluorobenzenesulfonyl chloride, DTXCID9038925, Benzenesulfonyl chloride, pfluoro, Benzenesulfonyl chloride, 4fluoro, bfxhjfkkrgvumu-uhfffaoysa-n, inchi=1/c6h4clfo2s/c7-11(9,10)6-3-1-5(8)2-4-6/h1-4h, un3261, 4-Fluorobenzene-1-Sulfonyl Chloride, 4-Fluorobenzenesulphonyl chloride, 4-fluorobenzenesulfonylchloride, 4-fluorobenzenesulfonic acid chloride, 4-fluoro-benzenesulfonyl chloride, MFCD00007438, 4-fluorobenzensulfonyl chloride, P-FLUOROBENZENESULPHONYL CHLORIDE, 2M9GLL38TN, 4-fluorophenylsulphonyl chloride, NSC-140128, chloro(4-fluorophenyl)sulfone, p-FC6H4SO2Cl, UNII-2M9GLL38TN, SCHEMBL17242, 4-fluorophenylsulfonylchloride, 4fluorobenzenesulfonyl chloride, p-fluorophenylsulfonyl chloride, 4-fluorobezenesulfonyl chloride, 4-flurobenzenesulfonyl chloride, p-fluorobenzenesulphonylchloride, p-flourobenzenesulfonyl chloride, 4-fluoro benzenesulfonylchloride, 4-fluoro-benzenesulfonylchloride, 4-fluorobenzene sulfonylchloride, 4-Fluorobenzenesulphonylchloride, 4-Fluoro-benzensulfonyl chloride, 4-fluorobenzene sulphonylchloride, 4-fluorophenyl sulfonyl chloride, p-fluoro benzenesulfonyl chloride, 4-fluoro benzenesulfonyl chloride, 4-fluorobenzene sulfonyl chloride, 4-fluorobenzene-sulfonyl chloride, (4-fluorophenyl)sulfonyl chloride, 4-fluoro-phenyl sulfonyl chloride, p-fluorobenzene sulphonyl chloride, 4-fluoro-benzenesulphonyl chloride, 4-fluorobenzene sulphonyl chloride, 4-fluorobenzene-sulphonyl chloride, 4-Fluoro benzene sulfonyl chloride, 4-fluoro-benzene sulfonyl chloride, 4-fluoro-benzene-sulfonyl chloride, 4-fluorobenzene-1-sulfonylchloride, BCP15286, Benzenesulphonyl chloride, p-fluoro-, Benzenesulphonyl chloride, 4-fluoro-, NSC140128, SBB058843, STL163968, 4-fluoro-benzene-1-sulfonyl chloride, 4-fluorobenzenesulphonic acid chloride, AKOS000120306, 4-Fluorobenzenesulfonyl chloride, 98%, CS-W008916, FF00435, GS-3219, BP-20273, DB-048708, F0202, NS00041646, ST51038593, EN300-17447, P20473, doi:10.14272/BFXHJFKKRGVUMU-UHFFFAOYSA-N.1, Z56940934, F0808-2036

Application

4-Fluorobenzenesulfonyl chloride is primarily employed as a key building block in the synthesis of sulfonamide derivatives, which are prevalent in drug discovery (e.g., antibacterial and antiviral agents). It also serves as a precursor for functionalized polymers and specialty chemicals requiring fluorinated sulfonyl groups. In materials science, it is used to modify surface properties or create sulfonated fluorinated monomers.

Safety and Hazards

GHS Hazard Statements

• H302 (36.2%): Harmful if swallowed [Warning Acute toxicity, oral]
• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

Precautionary Statements

• P260, P264, P270, P280, P301+P317, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P330, P363, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (36.2%)
• Skin Corr. 1B (100%)

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