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Atomfair 2-Methoxy-5-(trifluoromethyl)aniline C8H8F3NO CAS 349-65-5

2-Methoxy-5-(trifluoromethyl)aniline (CAS No. 349-65-5) is a high-purity aromatic amine derivative with the molecular formula C8H8F3NO. This specialized compound features a methoxy group and a trifluoromethyl group ortho and para to the aniline nitrogen, respectively, making it a valuable intermediate in synthetic organic chemistry. Its unique structure lends itself to applications in pharmaceuticals, agrochemicals, and advanced material science. Available in research quantities, this product is rigorously tested for consistency, purity, and stability, ensuring reliable performance in demanding laboratory and industrial processes. Suitable for use as a building block in heterocyclic synthesis, cross-coupling reactions, and fluorinated compound development.

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Description

2-Methoxy-5-(trifluoromethyl)aniline (CAS No. 349-65-5) is a high-purity aromatic amine derivative with the molecular formula C8H8F3NO. This specialized compound features a methoxy group and a trifluoromethyl group ortho and para to the aniline nitrogen, respectively, making it a valuable intermediate in synthetic organic chemistry. Its unique structure lends itself to applications in pharmaceuticals, agrochemicals, and advanced material science. Available in research quantities, this product is rigorously tested for consistency, purity, and stability, ensuring reliable performance in demanding laboratory and industrial processes. Suitable for use as a building block in heterocyclic synthesis, cross-coupling reactions, and fluorinated compound development.

Properties

  • CAS Number: 349-65-5
  • Complexity: 171
  • IUPAC Name: 2-methoxy-5-(trifluoromethyl)aniline
  • InChI: InChI=1S/C8H8F3NO/c1-13-7-3-2-5(4-6(7)12)8(9,10)11/h2-4H,12H2,1H3
  • InChI Key: RKUSRLUGUVDNKP-UHFFFAOYSA-N
  • Exact Mass: 191.05579836
  • Molecular Formula: C8H8F3NO
  • Molecular Weight: 191.15
  • SMILES: COC1=C(C=C(C=C1)C(F)(F)F)N
  • Topological: 35.3
  • Monoisotopic Mass: 191.05579836
  • Synonyms: 2-Methoxy-5-(trifluoromethyl)aniline, 349-65-5, DTXSID10344947, DTXCID40296021, 626-005-3, 3-Amino-4-methoxybenzotrifluoride, 2-Amino-4-trifluoromethylanisole, Benzenamine, 2-methoxy-5-(trifluoromethyl)-, MFCD00042486, 2-Methoxy-5-trifluoromethylaniline, 2-Methoxy-5-trifluoromethyl-phenylamine, 2-Methoxy-5-(trifluoromethyl)phenylamine, 4-trifluromethyl-o-anisidine, SCHEMBL330883, F3146-0169, CHEBI:194915, PVQWWVSJKITHLY-UHFFFAOYSA-N, PWQPHULFBIDCCZ-UHFFFAOYSA-N, HMS1659D05, 2-Amino-4-(trifluoromethyl)anisole, 2-methoxy-5-trifluoromethyl-aniline, 2-methoxy-5-(triluoromethyl)aniline, SBB061787, STK397547, 5-(Trifluoromethyl)-2-methoxyaniline, 2-methoxy-5-(trifluoromethyl) aniline, 2-methoxy-5-trifluoromethylphenylamine, AKOS000102083, 5-(Trifluoromethyl) -2-methoxyaniline, CS-W002211, PS-8358, 2-methoxy-5-(trifluoromethyl)benzenamine, SY024813, 2-Methoxy-5-(trifluoromethyl)phenylamine #, DB-020449, 2-Methoxy-5-(trifluoromethyl)aniline, 96%, M2212, ST45047084, VU0510740-1, EN300-257738, 6-Methoxy-.alpha.,.alpha.,.alpha.-trifluoro-m-toluidine, Z111782480, InChI=1/C8H8F3NO/c1-13-7-3-2-5(4-6(7)12)8(9,10)11/h2-4H,12H2,1H

Application

2-Methoxy-5-(trifluoromethyl)aniline is widely utilized as a key intermediate in the synthesis of pharmaceuticals, particularly in the development of active pharmaceutical ingredients (APIs) with enhanced bioavailability. Its trifluoromethyl group contributes to metabolic stability, making it valuable in agrochemical research for pesticide and herbicide formulations. Additionally, this compound serves as a precursor in the preparation of liquid crystals and specialty polymers, where its structural motifs influence material properties.

Safety and Hazards

GHS Hazard Statements

  • H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
  • H312 (98.8%): Harmful in contact with skin [Warning Acute toxicity, dermal]
  • H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H332 (98.8%): Harmful if inhaled [Warning Acute toxicity, inhalation]
  • H335 (98.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Acute Tox. 4 (100%)
  • Acute Tox. 4 (98.8%)
  • Skin Irrit. 2 (100%)
  • Eye Irrit. 2 (100%)
  • Acute Tox. 4 (98.8%)
  • STOT SE 3 (98.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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