Description

Methyl 2-(4-fluorophenyl)acetate (CAS No. 34837-84-8) is a high-purity fluorinated organic ester with the molecular formula C₉H₉FO₂. This compound is widely utilized in pharmaceutical and agrochemical research as a key intermediate for the synthesis of bioactive molecules. Its structure features a fluorophenyl group, enhancing its reactivity and utility in cross-coupling reactions, esterifications, and other fine chemical transformations. Suitable for laboratory-scale and industrial applications, our product is rigorously tested to ensure ≥98% purity (GC), with trace metals and moisture levels minimized for sensitive reactions. Packaged under inert gas to maintain stability, it is available in quantities ranging from grams to kilograms to meet diverse research needs.

Properties

• CAS Number: 34837-84-8
• Complexity: 151
• IUPAC Name: methyl 2-(4-fluorophenyl)acetate
• InChI: InChI=1S/C9H9FO2/c1-12-9(11)6-7-2-4-8(10)5-3-7/h2-5H,6H2,1H3
• InChI Key: AJPPKGMEHMXPMC-UHFFFAOYSA-N
• Exact Mass: 168.05865769
• Molecular Formula: C9H9FO2
• Molecular Weight: 168.16
• SMILES: COC(=O)CC1=CC=C(C=C1)F
• Topological: 26.3
• Monoisotopic Mass: 168.05865769
• Synonyms: methyl 2-(4-fluorophenyl)acetate, 34837-84-8, DTXSID90369799, DTXCID40320835, 642-792-6, methyl 4-fluorophenylacetate, METHYL 4-FLUOROPHENYLACETATE, 99, 4-Fluorophenylacetic acid methyl ester, MFCD00800608, methyl (4-fluorophenyl)acetate, Methyl 4-fluorophenyl acetate, (4-fluorophenyl)acetic acid methyl ester, Benzeneacetic acid, 4-fluoro-, methyl ester, methyl-4-fluorphenylacetate, Methyl p-fluorophenylacetate, methyl 4-fluorophenyl-acetate, methyl(4-fluorophenyl)acetate, SCHEMBL378218, AJPPKGMEHMXPMC-UHFFFAOYSA-N, AB7526, SBB017032, AKOS000279322, CS-W008065, DS-2818, 4-Fluorophenylacetic acid, methyl ester, 4-fluoro-phenyl-acetic acid methyl ester, SY041951, (4-fluorophenyl)-acetic acid methyl ester, (4-Fluoro-phenyl)-acetic acid methyl ester, DB-069082, ST50405131, EN300-157250

Application

Methyl 2-(4-fluorophenyl)acetate serves as a versatile building block in medicinal chemistry, particularly in the synthesis of fluorinated analogs of active pharmaceutical ingredients (APIs). It is employed in the development of non-steroidal anti-inflammatory drugs (NSAIDs) and CNS-targeting compounds due to its fluorophenyl moiety. Researchers also use it in agrochemical formulations to enhance the bioavailability of active ingredients. Its ester group allows for further functionalization via hydrolysis or transesterification.

Safety and Hazards

GHS Hazard Statements

• H302 (33.3%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (33.3%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.