Description

4-Chloro-2-fluorophenol (CAS No. 348-62-9) is a halogenated phenolic compound with the molecular formula C₆H₄ClFO. This high-purity reagent is synthesized for advanced research applications, offering exceptional quality and consistency. Its unique structure, featuring both chloro and fluoro substituents on the phenolic ring, makes it a valuable intermediate in organic synthesis, pharmaceutical development, and agrochemical research. The compound is supplied as a crystalline solid with ≥98% purity (GC), ensuring optimal performance in sensitive reactions. Proper storage at 2-8°C in a tightly sealed container is recommended to maintain stability. Suitable for use in nucleophilic aromatic substitution, cross-coupling reactions, and as a building block for complex molecular architectures. Handle with appropriate PPE in a well-ventilated area.

Properties

• CAS Number: 348-62-9
• Complexity: 99.1
• IUPAC Name: 4-chloro-2-fluoro-phenol
• InChI: InChI=1S/C6H4ClFO/c7-4-1-2-6(9)5(8)3-4/h1-3,9H
• InChI Key: ZKMUKBBWORLNLA-UHFFFAOYSA-N
• Exact Mass: 145.9934706
• Molecular Formula: C6H4ClFO
• Molecular Weight: 146.54
• SMILES: C1=CC(=C(C=C1Cl)F)O
• Topological: 20.2
• Monoisotopic Mass: 145.9934706
• Synonyms: 4-Chloro-2-fluorophenol, 348-62-9, DTXSID20188339, DTXCID00110830, 628-692-5, Phenol, 4-chloro-2-fluoro-, 4-chloro-2-fluoro-phenol, 2-fluoro-4-chlorophenol, MFCD00075030, 4-chloro-fluorophenol, SCHEMBL414136, SCHEMBL2849125, SCHEMBL18526975, 4-Chloro-2-fluorophenol, 99%, SBB086517, AKOS009075958, AC-3774, CS-W007711, PS-8947, SY021834, DB-011319, C2264, EN300-22911, Z147646796, InChI=1/C6H4ClFO/c7-4-1-2-6(9)5(8)3-4/h1-3,9

Application

4-Chloro-2-fluorophenol serves as a key intermediate in pharmaceutical synthesis, particularly for developing active pharmaceutical ingredients (APIs) with enhanced bioavailability. Researchers utilize this compound in agrochemical production to create novel pesticides and herbicides with improved selectivity. Its dual halogen functionality makes it valuable in material science for synthesizing advanced polymers and liquid crystals with tailored properties.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.