Description

2,5-Dichlorofluorobenzene (CAS No. 348-59-4) is a high-purity halogenated aromatic compound with the molecular formula C₆H₃Cl₂F. This specialty chemical is widely utilized in pharmaceutical synthesis, agrochemical production, and advanced material research due to its unique reactivity as a fluorinated building block. The product is supplied as a clear to pale-yellow liquid with a characteristic aromatic odor, offering excellent solubility in organic solvents like dichloromethane, ethanol, and ether while being practically insoluble in water. Our material meets stringent quality control standards with typical purity ≥98% by GC analysis, making it ideal for demanding synthetic applications. Proper handling requires PPE including nitrile gloves and vapor respirators due to potential irritant properties. Available in research quantities (100mg-25g) up to bulk industrial scales (kg-ton) with custom packaging options.

Properties

• CAS Number: 348-59-4
• Complexity: 97.1
• IUPAC Name: 1,4-dichloro-2-fluoro-benzene
• InChI: InChI=1S/C6H3Cl2F/c7-4-1-2-5(8)6(9)3-4/h1-3H
• InChI Key: BJQTYCQGIXZSNM-UHFFFAOYSA-N
• Exact Mass: 163.9595836
• Molecular Formula: C6H3Cl2F
• Molecular Weight: 164.99
• SMILES: C1=CC(=C(C=C1Cl)F)Cl
• Monoisotopic Mass: 163.9595836
• Synonyms: 2,5-Dichlorofluorobenzene, 671-125-1, 348-59-4, 1,4-dichloro-2-fluorobenzene, Benzene, 1,4-dichloro-2-fluoro-, 1,4-Dichloro-2-fluoro-benzene, MFCD00060656, 2,5-DICHLORO-1-FLUOROBENZENE, NSC10256, 1-Fluor-2,5-Dichlorbenzol, SCHEMBL529850, SCHEMBL741383, SCHEMBL974590, SCHEMBL976789, CHEMBL2263226, DTXSID00188337, Benzene,1,4-dichloro-2-fluoro-, NSC 10256, NSC-10256, SBB087863, AKOS006229633, CS-W016080, FS-4042, SY039913, DB-020049, D2513, ST50405137, EN300-100563

2,5-Dichlorofluorobenzene serves as a key intermediate in Suzuki coupling reactions for pharmaceutical API synthesis, particularly in the development of kinase inhibitors. The compound’s unique halogen pattern enables selective functionalization in agrochemical production of fungicides and herbicides. Researchers also employ it as a precursor for liquid crystal materials and specialty polymers requiring controlled fluorine incorporation.

Safety and Hazards

GHS Hazard Statements

• H227 (12.5%): Combustible liquid [Warning Flammable liquids]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (87.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403, P403+P233, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 4 (12.5%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (87.5%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.