Description

2,3,4,5-Tetrafluorophenol (CAS No. 3467-85-4) is a high-purity fluorinated phenolic compound with the molecular formula C₆H₂F₄O. This specialty chemical is characterized by its tetrafluorinated aromatic ring, which enhances its reactivity and suitability for advanced synthetic applications. With a molecular weight of 166.07 g/mol, it is a versatile building block in pharmaceutical, agrochemical, and material science research. The compound is supplied as a crystalline solid with >98% purity (HPLC), ensuring optimal performance in demanding reactions. Its unique electronic properties make it invaluable for nucleophilic aromatic substitution (S_NAr) reactions and as a precursor for liquid crystal materials. Proper storage at 2-8°C under inert atmosphere is recommended to maintain stability.

Properties

• CAS Number: 3467-85-4
• Complexity: 143
• IUPAC Name: 2,3,4,5-tetrafluorophenol
• InChI: InChI=1S/C6H2F4O/c7-2-1-3(11)5(9)6(10)4(2)8/h1,11H
• InChI Key: QXYLYYZZWZQACI-UHFFFAOYSA-N
• Exact Mass: 166.00417733
• Molecular Formula: C6H2F4O
• Molecular Weight: 166.07
• SMILES: C1=C(C(=C(C(=C1F)F)F)F)O
• Topological: 20.2
• Monoisotopic Mass: 166.00417733
• Synonyms: 2,3,4,5-Tetrafluorophenol, 3467-85-4, Phenol, 2,3,4,5-tetrafluoro-, tetrafluorophenol, SCHEMBL78177, SCHEMBL258682, SCHEMBL2474900, 2, 3, 4, 5-Tetrafluorophenol, QXYLYYZZWZQACI-UHFFFAOYSA-N, MFCD12032171, BS-49289, SY274345, CS-0199099, E75626, EN300-1601547

Application

2,3,4,5-Tetrafluorophenol serves as a key intermediate in the synthesis of fluorinated liquid crystals for display technologies. It is widely employed in pharmaceutical research for constructing bioactive molecules through its phenolic hydroxyl group. The compound’s electron-deficient aromatic ring facilitates efficient coupling reactions in agrochemical development. Researchers also utilize it as a derivatization agent in analytical chemistry for sensitive detection methods.

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