Description

2-Chloro-3-fluoro-5-methylpyridine (CAS No. 34552-15-3) is a high-purity halogenated pyridine derivative with the molecular formula C₆H₅ClFN. This heterocyclic compound features a chloro- and fluoro-substituted pyridine ring with a methyl group at the 5-position, offering unique reactivity for advanced synthetic applications. Optimized for pharmaceutical and agrochemical research, our product undergoes rigorous QC testing (HPLC, GC, NMR) to ensure ≥98% purity, batch-to-batch consistency, and low heavy metal content. Supplied in amber glass vials under inert atmosphere to prevent degradation. Ideal for Suzuki couplings, nucleophilic substitutions, and as a building block for bioactive molecules. Technical datasheet and COA available upon request.

Properties

• CAS Number: 34552-15-3
• Complexity: 99.1
• IUPAC Name: 2-chloro-3-fluoro-5-methyl-pyridine
• InChI: InChI=1S/C6H5ClFN/c1-4-2-5(8)6(7)9-3-4/h2-3H,1H3
• InChI Key: XZJURWKNRAGMCG-UHFFFAOYSA-N
• Exact Mass: 145.0094550
• Molecular Formula: C6H5ClFN
• Molecular Weight: 145.56
• SMILES: CC1=CC(=C(N=C1)Cl)F
• Topological: 12.9
• Monoisotopic Mass: 145.0094550
• Synonyms: 2-chloro-3-fluoro-5-methylpyridine, 34552-15-3, DTXSID80543283, DTXCID20494068, 675-593-8, 2-chloro-3-fluoro-5-picoline, 2-Chloro-3-fluoro-5-methyl-pyridine, MFCD06658238, 3-Fluoro-2-chloro-5-methylpyridine, Pyridine, 2-chloro-3-fluoro-5-methyl-, 6-Chloro-5-fluoro-3-picoline, 6-chloro-5-fluoro-3-methylpyridine, 2-Chloro-3-fluoro-5-methyl pyridine, SCHEMBL17892, SCHEMBL19813955, XZJURWKNRAGMCG-UHFFFAOYSA-N, BCP22120, CS-D0946, BBL101881, SBB054325, STL555678, AKOS005063651, PS-6415, AC-24936, SY018331, DB-008184, C3275, EN300-82814

Application

2-Chloro-3-fluoro-5-methylpyridine serves as a key intermediate in the synthesis of novel crop protection agents, particularly fungicides and herbicides targeting pyridine-dependent enzymes. Its halogenated structure enables efficient pharmaceutical derivatization for kinase inhibitors and CNS-active compounds. The methyl group enhances lipophilicity for improved bioavailability in drug development pipelines.

Safety and Hazards

GHS Hazard Statements

• H302 (33.3%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (33.3%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (66.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (66.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (33.3%)
• Skin Irrit. 2 (100%)
• Eye Dam. 1 (33.3%)
• Eye Irrit. 2 (66.7%)
• STOT SE 3 (66.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.