Description

2-Chloro-5-methylpyridin-3-amine (CAS No. 34552-13-1) is a high-purity heterocyclic organic compound with the molecular formula C₆H₇ClN₂. This fine chemical is a valuable intermediate in pharmaceutical and agrochemical synthesis, featuring a reactive chloro group and an amine functional group on a pyridine backbone. The compound is supplied as a crystalline solid with guaranteed purity levels suitable for research and industrial applications. Its unique structure makes it a versatile building block for the development of active pharmaceutical ingredients (APIs), ligands, and specialty chemicals. Proper storage under inert conditions is recommended to maintain stability.

Properties

• CAS Number: 34552-13-1
• Complexity: 97.1
• IUPAC Name: 2-chloro-5-methyl-pyridin-3-amine
• InChI: InChI=1S/C6H7ClN2/c1-4-2-5(8)6(7)9-3-4/h2-3H,8H2,1H3
• InChI Key: CQKIBEOVARIBDN-UHFFFAOYSA-N
• Exact Mass: 142.0297759
• Molecular Formula: C6H7ClN2
• Molecular Weight: 142.58
• SMILES: CC1=CC(=C(N=C1)Cl)N
• Topological: 38.9
• Monoisotopic Mass: 142.0297759
• Synonyms: 34552-13-1, 2-chloro-5-methylpyridin-3-amine, DTXSID50370301, DTXCID90321337, 624-418-3, 3-AMINO-2-CHLORO-5-METHYLPYRIDINE, 3-Amino-2-chloro-5-picoline, 5-Amino-6-chloro-3-picoline, MFCD03427656, 3-Amino-2-chloro–5-methylpyridine, 3-Pyridinamine, 2-chloro-5-methyl-, 2-CHLORO-5-METHYL-PYRIDIN-3-YLAMINE, SCHEMBL221321, 2-chloro-5-methyl-3-pyridylamine, 5-methyl-3-amino-2-chloropyridine, CS-D0774, BBL101168, SBB004139, STL554964, AKOS005257275, AB15085, DS-1468, Pyridine, 3-amino-2-chloro-5-methyl-, AC-24922, SY031475, 3-Amino-2-chloro-5-methylpyridine, 97%, DB-028324, A2405, EN300-92991, 2-chloro-5-methylpyridin-3-amine;3-Amino-2-chloro-5-methylpyridine, 2-chloro-5-methylpyridin-3-amine ; 3-Amino-2-chloro-5-methylpyridine

Application

2-Chloro-5-methylpyridin-3-amine serves as a key intermediate in medicinal chemistry for the synthesis of drug candidates targeting various therapeutic areas. The compound’s reactive sites enable its use in palladium-catalyzed cross-coupling reactions for constructing complex heterocycles. Researchers utilize this building block in the development of novel pesticides and herbicides due to its pyridine core structure. It also finds application in material science as a precursor for functionalized ligands in coordination chemistry.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (97.6%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (95.2%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H335 (95.2%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P330, P332+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Skin Irrit. 2 (97.6%)
• Eye Dam. 1 (95.2%)
• STOT SE 3 (95.2%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.