Description

4,4′-Difluorobenzophenone (CAS No. 345-92-6) is a high-purity fluorinated aromatic ketone with the molecular formula C₁₃H₈F₂O. This compound, also known by its IUPAC name bis(4-fluorophenyl)methanone, is a white to off-white crystalline powder with exceptional thermal and chemical stability. It is widely utilized as a key intermediate in pharmaceutical synthesis, advanced material science, and specialty polymer production. With a melting point of approximately 102-105°C, this reagent is soluble in common organic solvents such as acetone, ethanol, and dichloromethane. Our product is rigorously tested to ensure ≥98% purity (GC) and is supplied with comprehensive analytical documentation including HPLC, NMR, and MS spectra for research and industrial applications.

Properties

• CAS Number: 345-92-6
• Complexity: 214
• IUPAC Name: bis(4-fluorophenyl)methanone
• InChI: InChI=1S/C13H8F2O/c14-11-5-1-9(2-6-11)13(16)10-3-7-12(15)8-4-10/h1-8H
• InChI Key: LSQARZALBDFYQZ-UHFFFAOYSA-N
• Exact Mass: 218.05432120
• Molecular Formula: C13H8F2O
• Molecular Weight: 218.20
• SMILES: C1=CC(=CC=C1C(=O)C2=CC=C(C=C2)F)F
• Topological: 17.1
• Monoisotopic Mass: 218.05432120
• Physical Description: White crystalline powder;
• Synonyms: 4,4′-Difluorobenzophenone, Bis(4-fluorophenyl)methanone, bis(4-fluorophenyl)-methanone, Methanone, bis(4-fluorophenyl)-, Di-p-fluorophenyl ketone, p,p’-Difluorobenzophenone, Bis(p-fluorophenyl) ketone, Bis(4-fluorophenyl) ketone, NSC 51800, BENZOPHENONE, 4,4′-DIFLUORO-, EINECS 206-466-3, UNII-88BNC11B9C, BRN 0516231, 88BNC11B9C, NSC-51800, DTXSID30188062, EC 206-466-3, 4-07-00-01374 (Beilstein Handbook Reference), Dipfluorophenyl ketone, p,p’Difluorobenzophenone, Bis(pfluorophenyl) ketone, Bis(4fluorophenyl) ketone, Bis(4fluorophenyl)methanone, M-3-DFBP, Benzophenone, 4,4’difluoro, Methanone, bis(4fluorophenyl), DTXCID60110553, Methanone, bis(4fluorophenyl) (9CI), Methanone, bis(4-fluorophenyl)-(9CI), lsqarzalbdfyqz-uhfffaoysa-n, 345-92-6, MFCD00000353, 4,4′-difluorodiphenylmethanone, di4-fluorophenyl ketone, p-fluorophenyl ketone, rho-Fluorophenyl Ketone, p,p’-Difluorbenzophenon, WLN: FR DVR DF, 4,4′-Diflourobenzophenone, Benzophenone,4′-difluoro-, 4,4 ‘-difluorobenzophenone, SCHEMBL238259, 4,4”-Difluorodiphenyl ketone, Bis-(4-fluoro-phenyl)methanone, 4,4′-Difluorobenzophenone, 99%, NSC51800, MSK157250, SBB057283, AKOS005063569, CCG-245138, FD62650, AC-10924, DB-014390, CS-0015469, D1797, NS00011109, ST50307998, 4,4′-Difluorobenzophenone, analytical standard, D72510, EN300-118179, AE-848/31937058, Q4637051, 4,4’-Difluorobenzophenone, TraceCERT(R), certified reference material, 19F-qNMR Standard

Application

4,4′-Difluorobenzophenone serves as a critical building block in the synthesis of high-performance polymers, including poly(ether ether ketone) (PEEK) analogs. It is extensively used in pharmaceutical research for developing fluorinated drug candidates with enhanced metabolic stability. The compound also finds application in liquid crystal displays (LCDs) and advanced electronic materials due to its excellent thermal and optical properties.

Safety and Hazards

GHS Hazard Statements

• H302 (73.4%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (78.5%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (78.5%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (77.2%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H411 (73.4%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (73.4%)
• Skin Irrit. 2 (78.5%)
• Eye Irrit. 2 (78.5%)
• STOT SE 3 (77.2%)
• Aquatic Chronic 2 (73.4%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.